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Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia
Loss-of-function mutations in hematopoietic transcription factors including PAX5 occur in most cases of B-progenitor acute lymphoblastic leukemia (B-ALL), a disease characterized by the accumulation of undifferentiated lymphoblasts. Although PAX5 mutation is a critical driver of B-ALL development in...
Autores principales: | Liu, Grace J., Cimmino, Luisa, Jude, Julian G., Hu, Yifang, Witkowski, Matthew T., McKenzie, Mark D., Kartal-Kaess, Mutlu, Best, Sarah A., Tuohey, Laura, Liao, Yang, Shi, Wei, Mullighan, Charles G., Farrar, Michael A., Nutt, Stephen L., Smyth, Gordon K., Zuber, Johannes, Dickins, Ross A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066403/ https://www.ncbi.nlm.nih.gov/pubmed/24939936 http://dx.doi.org/10.1101/gad.240416.114 |
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