Oxidation of cellular amino acid pools leads to cytotoxic mistranslation of the genetic code

Aminoacyl-tRNA synthetases use a variety of mechanisms to ensure fidelity of the genetic code and ultimately select the correct amino acids to be used in protein synthesis. The physiological necessity of these quality control mechanisms in different environments remains unclear, as the cost vs benef...

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Detalles Bibliográficos
Autores principales: Bullwinkle, Tammy J, Reynolds, Noah M, Raina, Medha, Moghal, Adil, Matsa, Eleftheria, Rajkovic, Andrei, Kayadibi, Huseyin, Fazlollahi, Farbod, Ryan, Christopher, Howitz, Nathaniel, Faull, Kym F, Lazazzera, Beth A, Ibba, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066437/
https://www.ncbi.nlm.nih.gov/pubmed/24891238
http://dx.doi.org/10.7554/eLife.02501

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