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Plasma Brain-Type Natriuretic Peptide Level Following Seizure and Syncope: Pilot Study
BACKGROUND AND PURPOSE: To explore the clinical feasibility of plasma brain-type natriuretic peptide (proBNP) level to differentiate the two major causes of transient unconsciousness, seizure and vasovagal syncope (VVS) in adult patients. METHODS: ProBNP levels were evaluated within 24 hours followi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Epilepsy Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066628/ https://www.ncbi.nlm.nih.gov/pubmed/24977125 |
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author | Park, Kyung-Il |
author_facet | Park, Kyung-Il |
author_sort | Park, Kyung-Il |
collection | PubMed |
description | BACKGROUND AND PURPOSE: To explore the clinical feasibility of plasma brain-type natriuretic peptide (proBNP) level to differentiate the two major causes of transient unconsciousness, seizure and vasovagal syncope (VVS) in adult patients. METHODS: ProBNP levels were evaluated within 24 hours following attack in patients who had experienced a transient episode of unconsciousness. For confirmatory diagnosis, clinical history was reviewed thoroughly and several work-ups including electroencephalography and cerebral imaging and tilt-table test, were performed in cases of putative VVS, as a part of routine clinical approaches. RESULTS: According to various relevant evaluations, 15 patients were diagnosed as seizure (age, 40.3±13.8 years) and 12 patients were VVS (age, 38.1±17.1 years). Plasma concentrations of pro-BNP were not different between two groups (p=0.714). Median level was 34.3 pg/mL (interquartile range: 12.9–91.1) in post-seizure group and 32.3 pg/mL (interquartile range 8.9–77.4) in post-VVS group. Additionally, it was not correlated with the sampling times within 24 hours after the episodes. CONCLUSIONS: The plasma level of pro-BNP has a limited clinical value in differentiating seizure and vasovagal syncope in adults. However, the more validated results with a large population should be sought in the future studies to confirm its value. |
format | Online Article Text |
id | pubmed-4066628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Korean Epilepsy Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-40666282014-06-30 Plasma Brain-Type Natriuretic Peptide Level Following Seizure and Syncope: Pilot Study Park, Kyung-Il J Epilepsy Res Original Article BACKGROUND AND PURPOSE: To explore the clinical feasibility of plasma brain-type natriuretic peptide (proBNP) level to differentiate the two major causes of transient unconsciousness, seizure and vasovagal syncope (VVS) in adult patients. METHODS: ProBNP levels were evaluated within 24 hours following attack in patients who had experienced a transient episode of unconsciousness. For confirmatory diagnosis, clinical history was reviewed thoroughly and several work-ups including electroencephalography and cerebral imaging and tilt-table test, were performed in cases of putative VVS, as a part of routine clinical approaches. RESULTS: According to various relevant evaluations, 15 patients were diagnosed as seizure (age, 40.3±13.8 years) and 12 patients were VVS (age, 38.1±17.1 years). Plasma concentrations of pro-BNP were not different between two groups (p=0.714). Median level was 34.3 pg/mL (interquartile range: 12.9–91.1) in post-seizure group and 32.3 pg/mL (interquartile range 8.9–77.4) in post-VVS group. Additionally, it was not correlated with the sampling times within 24 hours after the episodes. CONCLUSIONS: The plasma level of pro-BNP has a limited clinical value in differentiating seizure and vasovagal syncope in adults. However, the more validated results with a large population should be sought in the future studies to confirm its value. Korean Epilepsy Society 2014-06-30 /pmc/articles/PMC4066628/ /pubmed/24977125 Text en Copyright©2014 Korean Epilepsy Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Park, Kyung-Il Plasma Brain-Type Natriuretic Peptide Level Following Seizure and Syncope: Pilot Study |
title | Plasma Brain-Type Natriuretic Peptide Level Following Seizure and Syncope: Pilot Study |
title_full | Plasma Brain-Type Natriuretic Peptide Level Following Seizure and Syncope: Pilot Study |
title_fullStr | Plasma Brain-Type Natriuretic Peptide Level Following Seizure and Syncope: Pilot Study |
title_full_unstemmed | Plasma Brain-Type Natriuretic Peptide Level Following Seizure and Syncope: Pilot Study |
title_short | Plasma Brain-Type Natriuretic Peptide Level Following Seizure and Syncope: Pilot Study |
title_sort | plasma brain-type natriuretic peptide level following seizure and syncope: pilot study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066628/ https://www.ncbi.nlm.nih.gov/pubmed/24977125 |
work_keys_str_mv | AT parkkyungil plasmabraintypenatriureticpeptidelevelfollowingseizureandsyncopepilotstudy |