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Plasma Brain-Type Natriuretic Peptide Level Following Seizure and Syncope: Pilot Study

BACKGROUND AND PURPOSE: To explore the clinical feasibility of plasma brain-type natriuretic peptide (proBNP) level to differentiate the two major causes of transient unconsciousness, seizure and vasovagal syncope (VVS) in adult patients. METHODS: ProBNP levels were evaluated within 24 hours followi...

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Autor principal: Park, Kyung-Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Epilepsy Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066628/
https://www.ncbi.nlm.nih.gov/pubmed/24977125
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author Park, Kyung-Il
author_facet Park, Kyung-Il
author_sort Park, Kyung-Il
collection PubMed
description BACKGROUND AND PURPOSE: To explore the clinical feasibility of plasma brain-type natriuretic peptide (proBNP) level to differentiate the two major causes of transient unconsciousness, seizure and vasovagal syncope (VVS) in adult patients. METHODS: ProBNP levels were evaluated within 24 hours following attack in patients who had experienced a transient episode of unconsciousness. For confirmatory diagnosis, clinical history was reviewed thoroughly and several work-ups including electroencephalography and cerebral imaging and tilt-table test, were performed in cases of putative VVS, as a part of routine clinical approaches. RESULTS: According to various relevant evaluations, 15 patients were diagnosed as seizure (age, 40.3±13.8 years) and 12 patients were VVS (age, 38.1±17.1 years). Plasma concentrations of pro-BNP were not different between two groups (p=0.714). Median level was 34.3 pg/mL (interquartile range: 12.9–91.1) in post-seizure group and 32.3 pg/mL (interquartile range 8.9–77.4) in post-VVS group. Additionally, it was not correlated with the sampling times within 24 hours after the episodes. CONCLUSIONS: The plasma level of pro-BNP has a limited clinical value in differentiating seizure and vasovagal syncope in adults. However, the more validated results with a large population should be sought in the future studies to confirm its value.
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spelling pubmed-40666282014-06-30 Plasma Brain-Type Natriuretic Peptide Level Following Seizure and Syncope: Pilot Study Park, Kyung-Il J Epilepsy Res Original Article BACKGROUND AND PURPOSE: To explore the clinical feasibility of plasma brain-type natriuretic peptide (proBNP) level to differentiate the two major causes of transient unconsciousness, seizure and vasovagal syncope (VVS) in adult patients. METHODS: ProBNP levels were evaluated within 24 hours following attack in patients who had experienced a transient episode of unconsciousness. For confirmatory diagnosis, clinical history was reviewed thoroughly and several work-ups including electroencephalography and cerebral imaging and tilt-table test, were performed in cases of putative VVS, as a part of routine clinical approaches. RESULTS: According to various relevant evaluations, 15 patients were diagnosed as seizure (age, 40.3±13.8 years) and 12 patients were VVS (age, 38.1±17.1 years). Plasma concentrations of pro-BNP were not different between two groups (p=0.714). Median level was 34.3 pg/mL (interquartile range: 12.9–91.1) in post-seizure group and 32.3 pg/mL (interquartile range 8.9–77.4) in post-VVS group. Additionally, it was not correlated with the sampling times within 24 hours after the episodes. CONCLUSIONS: The plasma level of pro-BNP has a limited clinical value in differentiating seizure and vasovagal syncope in adults. However, the more validated results with a large population should be sought in the future studies to confirm its value. Korean Epilepsy Society 2014-06-30 /pmc/articles/PMC4066628/ /pubmed/24977125 Text en Copyright©2014 Korean Epilepsy Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Kyung-Il
Plasma Brain-Type Natriuretic Peptide Level Following Seizure and Syncope: Pilot Study
title Plasma Brain-Type Natriuretic Peptide Level Following Seizure and Syncope: Pilot Study
title_full Plasma Brain-Type Natriuretic Peptide Level Following Seizure and Syncope: Pilot Study
title_fullStr Plasma Brain-Type Natriuretic Peptide Level Following Seizure and Syncope: Pilot Study
title_full_unstemmed Plasma Brain-Type Natriuretic Peptide Level Following Seizure and Syncope: Pilot Study
title_short Plasma Brain-Type Natriuretic Peptide Level Following Seizure and Syncope: Pilot Study
title_sort plasma brain-type natriuretic peptide level following seizure and syncope: pilot study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066628/
https://www.ncbi.nlm.nih.gov/pubmed/24977125
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