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Toxicity Profile of a Nutraceutical Formulation Derived from Green Mussel Perna viridis

The short-term (acute) and long-term (subchronic) toxicity profile, mean lethal dose 50 (LD(50)), and no-observed-adverse-effect level (NOAEL) of a nutraceutical formulation developed from green mussel Perna viridis, which showed in vitro and in vivo anti-inflammatory properties, were evaluated in t...

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Autores principales: Chakraborty, Kajal, Joseph, Deepu, Chakkalakal, Selsa J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066681/
https://www.ncbi.nlm.nih.gov/pubmed/24995298
http://dx.doi.org/10.1155/2014/471565
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author Chakraborty, Kajal
Joseph, Deepu
Chakkalakal, Selsa J.
author_facet Chakraborty, Kajal
Joseph, Deepu
Chakkalakal, Selsa J.
author_sort Chakraborty, Kajal
collection PubMed
description The short-term (acute) and long-term (subchronic) toxicity profile, mean lethal dose 50 (LD(50)), and no-observed-adverse-effect level (NOAEL) of a nutraceutical formulation developed from green mussel Perna viridis, which showed in vitro and in vivo anti-inflammatory properties, were evaluated in the present study. The formulation was administered to the male and female Wistar rats at graded doses (0.5, 1.0, and 2.5 g/kg body weight) for two weeks of acute toxicity study and 0.5, 1.0, and 2.0 g/kg body weight for 90 days in subchronic toxicity study. The LD(50), variations in clinical signs, changes in body weight, body weight, food/water consumption, organ weight (liver, kidney, spleen, and brain), hematology, serum chemistry, and histopathological changes were evaluated. The LD(50) of the formulation was 5,000 mg/kg BW. No test article related mortalities as well as change in body weight, and food and water consumption were observed. No toxicity related significant changes were noted in renal/hepatic function, hematological indices, and serum biochemical parameters between the control and treated groups. Histopathological alterations were not observed in the vital organs of rats. The subchronic NOAEL for the formulation in rats is greater than 2000 mg/kg. This study demonstrated that the green mussel formulation is safe to consume without any adverse effects in the body.
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spelling pubmed-40666812014-07-03 Toxicity Profile of a Nutraceutical Formulation Derived from Green Mussel Perna viridis Chakraborty, Kajal Joseph, Deepu Chakkalakal, Selsa J. Biomed Res Int Research Article The short-term (acute) and long-term (subchronic) toxicity profile, mean lethal dose 50 (LD(50)), and no-observed-adverse-effect level (NOAEL) of a nutraceutical formulation developed from green mussel Perna viridis, which showed in vitro and in vivo anti-inflammatory properties, were evaluated in the present study. The formulation was administered to the male and female Wistar rats at graded doses (0.5, 1.0, and 2.5 g/kg body weight) for two weeks of acute toxicity study and 0.5, 1.0, and 2.0 g/kg body weight for 90 days in subchronic toxicity study. The LD(50), variations in clinical signs, changes in body weight, body weight, food/water consumption, organ weight (liver, kidney, spleen, and brain), hematology, serum chemistry, and histopathological changes were evaluated. The LD(50) of the formulation was 5,000 mg/kg BW. No test article related mortalities as well as change in body weight, and food and water consumption were observed. No toxicity related significant changes were noted in renal/hepatic function, hematological indices, and serum biochemical parameters between the control and treated groups. Histopathological alterations were not observed in the vital organs of rats. The subchronic NOAEL for the formulation in rats is greater than 2000 mg/kg. This study demonstrated that the green mussel formulation is safe to consume without any adverse effects in the body. Hindawi Publishing Corporation 2014 2014-06-09 /pmc/articles/PMC4066681/ /pubmed/24995298 http://dx.doi.org/10.1155/2014/471565 Text en Copyright © 2014 Kajal Chakraborty et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chakraborty, Kajal
Joseph, Deepu
Chakkalakal, Selsa J.
Toxicity Profile of a Nutraceutical Formulation Derived from Green Mussel Perna viridis
title Toxicity Profile of a Nutraceutical Formulation Derived from Green Mussel Perna viridis
title_full Toxicity Profile of a Nutraceutical Formulation Derived from Green Mussel Perna viridis
title_fullStr Toxicity Profile of a Nutraceutical Formulation Derived from Green Mussel Perna viridis
title_full_unstemmed Toxicity Profile of a Nutraceutical Formulation Derived from Green Mussel Perna viridis
title_short Toxicity Profile of a Nutraceutical Formulation Derived from Green Mussel Perna viridis
title_sort toxicity profile of a nutraceutical formulation derived from green mussel perna viridis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066681/
https://www.ncbi.nlm.nih.gov/pubmed/24995298
http://dx.doi.org/10.1155/2014/471565
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