Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population

BACKGROUND: The aim of this study was to determine whether the serotonin transporter gene (5-HTT), a key component in the control of the serotonergic system, is associated with endometriosis in an Italian population. FINDINGS: A case–control study, comprising 137 Italian patients with surgically con...

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Detalles Bibliográficos
Autores principales: Megiorni, Francesca, Resta, Serena, Yazdanian, Deliar, Cavaggioni, Gabriele, Lia, Claudia, Benedetti Panici, Pierluigi, Pizzuti, Antonio, Porpora, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066692/
https://www.ncbi.nlm.nih.gov/pubmed/24925205
http://dx.doi.org/10.1186/1477-5751-13-12
Descripción
Sumario:BACKGROUND: The aim of this study was to determine whether the serotonin transporter gene (5-HTT), a key component in the control of the serotonergic system, is associated with endometriosis in an Italian population. FINDINGS: A case–control study, comprising 137 Italian patients with surgically confirmed endometriosis and 120 healthy controls, was carried out. 5-HTT genotypes (LL, SL and SS) were obtained by polymerase chain reaction and gel electrophoresis analysis. We found no overall difference in genotypic and allelic distributions of the 5-HTT gene between cases and controls. CONCLUSIONS: Our results suggest that the 5-HTT L/S promoter polymorphism is not associated with susceptibility to endometriosis in the studied Italian patients.

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