Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population

BACKGROUND: The aim of this study was to determine whether the serotonin transporter gene (5-HTT), a key component in the control of the serotonergic system, is associated with endometriosis in an Italian population. FINDINGS: A case–control study, comprising 137 Italian patients with surgically con...

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Autores principales: Megiorni, Francesca, Resta, Serena, Yazdanian, Deliar, Cavaggioni, Gabriele, Lia, Claudia, Benedetti Panici, Pierluigi, Pizzuti, Antonio, Porpora, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066692/
https://www.ncbi.nlm.nih.gov/pubmed/24925205
http://dx.doi.org/10.1186/1477-5751-13-12
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author Megiorni, Francesca
Resta, Serena
Yazdanian, Deliar
Cavaggioni, Gabriele
Lia, Claudia
Benedetti Panici, Pierluigi
Pizzuti, Antonio
Porpora, Maria Grazia
author_facet Megiorni, Francesca
Resta, Serena
Yazdanian, Deliar
Cavaggioni, Gabriele
Lia, Claudia
Benedetti Panici, Pierluigi
Pizzuti, Antonio
Porpora, Maria Grazia
author_sort Megiorni, Francesca
collection PubMed
description BACKGROUND: The aim of this study was to determine whether the serotonin transporter gene (5-HTT), a key component in the control of the serotonergic system, is associated with endometriosis in an Italian population. FINDINGS: A case–control study, comprising 137 Italian patients with surgically confirmed endometriosis and 120 healthy controls, was carried out. 5-HTT genotypes (LL, SL and SS) were obtained by polymerase chain reaction and gel electrophoresis analysis. We found no overall difference in genotypic and allelic distributions of the 5-HTT gene between cases and controls. CONCLUSIONS: Our results suggest that the 5-HTT L/S promoter polymorphism is not associated with susceptibility to endometriosis in the studied Italian patients.
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spelling pubmed-40666922014-06-24 Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population Megiorni, Francesca Resta, Serena Yazdanian, Deliar Cavaggioni, Gabriele Lia, Claudia Benedetti Panici, Pierluigi Pizzuti, Antonio Porpora, Maria Grazia J Negat Results Biomed Brief Report BACKGROUND: The aim of this study was to determine whether the serotonin transporter gene (5-HTT), a key component in the control of the serotonergic system, is associated with endometriosis in an Italian population. FINDINGS: A case–control study, comprising 137 Italian patients with surgically confirmed endometriosis and 120 healthy controls, was carried out. 5-HTT genotypes (LL, SL and SS) were obtained by polymerase chain reaction and gel electrophoresis analysis. We found no overall difference in genotypic and allelic distributions of the 5-HTT gene between cases and controls. CONCLUSIONS: Our results suggest that the 5-HTT L/S promoter polymorphism is not associated with susceptibility to endometriosis in the studied Italian patients. BioMed Central 2014-06-12 /pmc/articles/PMC4066692/ /pubmed/24925205 http://dx.doi.org/10.1186/1477-5751-13-12 Text en Copyright © 2014 Megiorni et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Brief Report
Megiorni, Francesca
Resta, Serena
Yazdanian, Deliar
Cavaggioni, Gabriele
Lia, Claudia
Benedetti Panici, Pierluigi
Pizzuti, Antonio
Porpora, Maria Grazia
Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population
title Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population
title_full Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population
title_fullStr Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population
title_full_unstemmed Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population
title_short Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population
title_sort lack of association between serotonin transporter 5-htt gene polymorphism and endometriosis in an italian patient population
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066692/
https://www.ncbi.nlm.nih.gov/pubmed/24925205
http://dx.doi.org/10.1186/1477-5751-13-12
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