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Comparison of non-canonical PAMs for CRISPR/Cas9-mediated DNA cleavage in human cells

CRISPR/Cas9 -mediated DNA cleavage (CCMDC) is becoming increasingly used for efficient genome engineering. Proto-spacer adjacent motif (PAM) adjacent to target sequence is one of the key components in the design of CCMDC strategies. It has been reported that NAG sequences are the predominant non-can...

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Detalles Bibliográficos
Autores principales:	Zhang, Yilan, Ge, Xianglian, Yang, Fayu, Zhang, Liping, Zheng, Jiayong, Tan, Xuefang, Jin, Zi-Bing, Qu, Jia, Gu, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066725/ https://www.ncbi.nlm.nih.gov/pubmed/24956376 http://dx.doi.org/10.1038/srep05405

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