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Disease-associated CAG·CTG triplet repeats expand rapidly in non-dividing mouse cells, but cell cycle arrest is insufficient to drive expansion

Genetically unstable expanded CAG·CTG trinucleotide repeats are causal in a number of human disorders, including Huntington disease and myotonic dystrophy type 1. It is still widely assumed that DNA polymerase slippage during replication plays an important role in the accumulation of expansions. Nev...

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Detalles Bibliográficos
Autores principales:	Gomes-Pereira, Mário, Hilley, James D., Morales, Fernando, Adam, Berit, James, Helen E., Monckton, Darren G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066746/ https://www.ncbi.nlm.nih.gov/pubmed/24860168 http://dx.doi.org/10.1093/nar/gku285

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