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Synthesis of structurally diverse major groove DNA interstrand crosslinks using three different aldehyde precursors

DNA interstrand crosslinks (ICLs) are extremely cytotoxic lesions that block essential cellular processes, such as replication and transcription. Crosslinking agents are widely used in cancer chemotherapy and form an array of structurally diverse ICLs. Despite the clinical success of these agents, r...

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Detalles Bibliográficos
Autores principales:	Mukherjee, Shivam, Guainazzi, Angelo, Schärer, Orlando D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Synthetic Biology and Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066762/ https://www.ncbi.nlm.nih.gov/pubmed/24782532 http://dx.doi.org/10.1093/nar/gku328

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