Distinct nucleic acid interaction properties of HIV-1 nucleocapsid protein precursor NCp15 explain reduced viral infectivity

During human immunodeficiency virus type 1 (HIV-1) maturation, three different forms of nucleocapsid (NC) protein—NCp15 (p9 + p6), NCp9 (p7 + SP2) and NCp7—appear successively. A mutant virus expressing NCp15 shows greatly reduced infectivity. Mature NCp7 is a chaperone protein that facilitates remo...

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Detalles Bibliográficos
Autores principales: Wang, Wei, Naiyer, Nada, Mitra, Mithun, Li, Jialin, Williams, Mark C., Rouzina, Ioulia, Gorelick, Robert J., Wu, Zhengrong, Musier-Forsyth, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066767/
https://www.ncbi.nlm.nih.gov/pubmed/24813443
http://dx.doi.org/10.1093/nar/gku335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066767/
https://www.ncbi.nlm.nih.gov/pubmed/24813443
http://dx.doi.org/10.1093/nar/gku335

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