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Specificity determinants for the two tRNA substrates of the cyclodipeptide synthase AlbC from Streptomyces noursei

Cyclodipeptide synthases (CDPSs) use two aminoacyl-tRNA substrates in a sequential ping-pong mechanism to form a cyclodipeptide. The crystal structures of three CDPSs have been determined and all show a Rossmann-fold domain similar to the catalytic domain of class-I aminoacyl-tRNA synthetases (aaRSs...

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Detalles Bibliográficos
Autores principales:	Moutiez, Mireille, Seguin, Jérôme, Fonvielle, Matthieu, Belin, Pascal, Jacques, Isabelle Béatrice, Favry, Emmanuel, Arthur, Michel, Gondry, Muriel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066775/ https://www.ncbi.nlm.nih.gov/pubmed/24782519 http://dx.doi.org/10.1093/nar/gku348

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