TAF7L modulates brown adipose tissue formation

Brown adipose tissue (BAT) plays an essential role in metabolic homeostasis by dissipating energy via thermogenesis through uncoupling protein 1 (UCP1). Previously, we reported that the TATA-binding protein associated factor 7L (TAF7L) is an important regulator of white adipose tissue (WAT) differen...

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Detalles Bibliográficos
Autores principales: Zhou, Haiying, Wan, Bo, Grubisic, Ivan, Kaplan, Tommy, Tjian, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066819/
https://www.ncbi.nlm.nih.gov/pubmed/24876128
http://dx.doi.org/10.7554/eLife.02811
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author Zhou, Haiying
Wan, Bo
Grubisic, Ivan
Kaplan, Tommy
Tjian, Robert
author_facet Zhou, Haiying
Wan, Bo
Grubisic, Ivan
Kaplan, Tommy
Tjian, Robert
author_sort Zhou, Haiying
collection PubMed
description Brown adipose tissue (BAT) plays an essential role in metabolic homeostasis by dissipating energy via thermogenesis through uncoupling protein 1 (UCP1). Previously, we reported that the TATA-binding protein associated factor 7L (TAF7L) is an important regulator of white adipose tissue (WAT) differentiation. In this study, we show that TAF7L also serves as a molecular switch between brown fat and muscle lineages in vivo and in vitro. In adipose tissue, TAF7L-containing TFIID complexes associate with PPARγ to mediate DNA looping between distal enhancers and core promoter elements. Our findings suggest that the presence of the tissue-specific TAF7L subunit in TFIID functions to promote long-range chromatin interactions during BAT lineage specification. DOI: http://dx.doi.org/10.7554/eLife.02811.001
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spelling pubmed-40668192014-06-27 TAF7L modulates brown adipose tissue formation Zhou, Haiying Wan, Bo Grubisic, Ivan Kaplan, Tommy Tjian, Robert eLife Developmental Biology and Stem Cells Brown adipose tissue (BAT) plays an essential role in metabolic homeostasis by dissipating energy via thermogenesis through uncoupling protein 1 (UCP1). Previously, we reported that the TATA-binding protein associated factor 7L (TAF7L) is an important regulator of white adipose tissue (WAT) differentiation. In this study, we show that TAF7L also serves as a molecular switch between brown fat and muscle lineages in vivo and in vitro. In adipose tissue, TAF7L-containing TFIID complexes associate with PPARγ to mediate DNA looping between distal enhancers and core promoter elements. Our findings suggest that the presence of the tissue-specific TAF7L subunit in TFIID functions to promote long-range chromatin interactions during BAT lineage specification. DOI: http://dx.doi.org/10.7554/eLife.02811.001 eLife Sciences Publications, Ltd 2014-05-29 /pmc/articles/PMC4066819/ /pubmed/24876128 http://dx.doi.org/10.7554/eLife.02811 Text en Copyright © 2014, Zhou et al http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Developmental Biology and Stem Cells
Zhou, Haiying
Wan, Bo
Grubisic, Ivan
Kaplan, Tommy
Tjian, Robert
TAF7L modulates brown adipose tissue formation
title TAF7L modulates brown adipose tissue formation
title_full TAF7L modulates brown adipose tissue formation
title_fullStr TAF7L modulates brown adipose tissue formation
title_full_unstemmed TAF7L modulates brown adipose tissue formation
title_short TAF7L modulates brown adipose tissue formation
title_sort taf7l modulates brown adipose tissue formation
topic Developmental Biology and Stem Cells
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066819/
https://www.ncbi.nlm.nih.gov/pubmed/24876128
http://dx.doi.org/10.7554/eLife.02811
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AT grubisicivan taf7lmodulatesbrownadiposetissueformation
AT kaplantommy taf7lmodulatesbrownadiposetissueformation
AT tjianrobert taf7lmodulatesbrownadiposetissueformation

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