Cargando…

Complex of the herpes simplex virus type 1 origin binding protein UL9 with DNA as a platform for the design of a new type of antiviral drugs

The herpes simplex virus type 1 origin-binding protein, OBP, is a DNA helicase encoded by the UL9 gene. The protein binds in a sequence-specific manner to the viral origins of replication, two OriS sites and one OriL site. In order to search for efficient inhibitors of the OBP activity, we have obta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bazhulina, N.P., Surovaya, A.N., Gursky, Y.G., Andronova, V.L., Moiseeva, E.D., Nikitin, A.M., Golovkin, M.V., Galegov, G.A., Grokhovsky, S.L., Gursky, G.V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066892/ https://www.ncbi.nlm.nih.gov/pubmed/23879454 http://dx.doi.org/10.1080/07391102.2013.820110

Ejemplares similares

Study of Antiherpetic Efficiency of Phosphite of Acycloguanosine Ableto Over come the Barrier of Resistance to Acyclovir
por: Andronova, V. L., et al.
Publicado: (2016)

The UL15 protein of herpes simplex virus type 1 is necessary for the localization of the UL28 and UL33 proteins to viral DNA replication centres
por: Higgs, Martin R., et al.
Publicado: (2008)

Large Subunit of the Human Herpes Simplex Virus Terminase as a Promising Target in Design of Anti-Herpesvirus Agents
por: Krasnov, Victor P., et al.
Publicado: (2023)

Generation and Characterization of UL21-Null Herpes Simplex Virus Type 1
por: Muto, Yoshifumi, et al.
Publicado: (2012)

Predicted Structure and Functions of the Prototypic Alphaherpesvirus Herpes Simplex Virus Type-1 UL37 Tegument Protein
por: Collantes, Therese Marie A., et al.
Publicado: (2022)

Dynamical Modeling of the Core Gene Network Controlling Flowering Suggests Cumulative Activation From the FLOWERING LOCUS T Gene Homologs in Chickpea
por: Gursky, Vitaly V., et al.
Publicado: (2018)

Dynamical Modeling of the Core Gene Network Controlling Transition to Flowering in Pisum sativum
por: Pavlinova, Polina, et al.
Publicado: (2021)

Developing oncolytic Herpes simplex virus type 1 through UL39 knockout by CRISPR-Cas9
por: Ebrahimi, Saeedeh, et al.
Publicado: (2020)

Identification of proteins that interact with the UL24 protein of herpes simplex virus 1
por: Bertrand, L, et al.
Publicado: (2011)

Immunological Identification and Characterization of the Capsid Scaffold Protein Encoded by UL26.5 of Herpes Simplex Virus Type 2
por: Li, Xueqi, et al.
Publicado: (2021)

Application of Domain- and Genotype-Specific Models to Infer Post-Transcriptional Regulation of Segmentation Gene Expression in Drosophila
por: Duk, Maria A., et al.
Publicado: (2021)

Structural Basis for Vital Function and Malfunction of Serum Amyloid A: an Acute-Phase Protein that Wears Hydrophobicity on Its Sleeve
por: Gursky, Olga
Publicado: (2020)

In silico evolution of the Drosophila gap gene regulatory sequence under elevated mutational pressure
por: Chertkova, Aleksandra A., et al.
Publicado: (2017)

Dual Function of the pUL7-pUL51 Tegument Protein Complex in Herpes Simplex Virus 1 Infection
por: Albecka, Anna, et al.
Publicado: (2017)

The herpes simplex virus UL20 protein functions in glycoprotein K (gK) intracellular transport and virus-induced cell fusion are independent of UL20 functions in cytoplasmic virion envelopment
por: Melancon, Jeffrey M, et al.
Publicado: (2007)

The herpes simplex virus type 1 DNA polymerase processivity factor, UL42, does not alter the catalytic activity of the UL9 origin-binding protein but facilitates its loading onto DNA
por: Trego, Kelly S., et al.
Publicado: (2005)

Functional Domains of the Herpes Simplex Virus Type 1 Tegument Protein pUL37: The Amino Terminus is Dispensable for Virus Replication in Tissue Culture
por: Grzesik, Peter, et al.
Publicado: (2019)

Herpes Simplex Virus Type 1 Clinical Isolates Respond to UL29-Targeted siRNA Swarm Treatment Independent of Their Acyclovir Sensitivity
por: Kalke, Kiira, et al.
Publicado: (2020)

Herpes simplex virus type 1 UL14 tegument protein regulates intracellular compartmentalization of major tegument protein VP16
por: Ohta, Akane, et al.
Publicado: (2011)

Human Plasma Very Low-Density Lipoproteins Are Stabilized by Electrostatic Interactions and Destabilized by Acidic pH
por: Guha, Madhumita, et al.
Publicado: (2011)

X-ray astronomy
por: Giacconi, Riccardo, et al.
Publicado: (1974)

CIME Summer School Geometric Analysis
por: Gursky, Matthew, et al.
Publicado: (2020)

Synthesis of Pyrimidine Conjugates with 4-(6-Amino-hexanoyl)-7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and Evaluation of Their Antiviral Activity
por: Krasnov, Victor P., et al.
Publicado: (2022)

CRISPR/Cas9 Mutagenesis of UL21 in Multiple Strains of Herpes Simplex Virus Reveals Differential Requirements for pUL21 in Viral Replication
por: Finnen, Renée L., et al.
Publicado: (2018)

Inner tegument protein pUL37 of herpes simplex virus type 1 is involved in directing capsids to the trans-Golgi network for envelopment
por: Pasdeloup, David, et al.
Publicado: (2010)

pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread
por: Benedyk, Tomasz H., et al.
Publicado: (2021)

Annual Meeting : Neutron stars, black holes and binary x-ray sources
por: Gursky, Herbert, et al.
Publicado: (1975)

Analysis of functional importance of binding sites in the Drosophila gap gene network model
por: Kozlov, Konstantin, et al.
Publicado: (2015)

Herpes Simplex Virus 1 UL37 Protein Tyrosine Residues Conserved among All Alphaherpesviruses Are Required for Interactions with Glycoprotein K, Cytoplasmic Virion Envelopment, and Infectious Virus Production
por: Chouljenko, Dmitry V., et al.
Publicado: (2016)

Role of the viral protein UL24 in nucleolar modifications induced by herpes simplex virus 1
por: Pearson, Angela, et al.
Publicado: (2011)

Expression, Purification, and Antiserum Production of the Truncated UL31 Protein of Herpes Simplex Virus 1
por: Zou, Xingmei, et al.
Publicado: (2019)

The Molecular Mechanism of Herpes Simplex Virus 1 UL31 in Antagonizing the Activity of IFN-β
por: Gong, Lan, et al.
Publicado: (2022)

Translating natural genetic variation to gene expression in a computational model of the Drosophila gap gene regulatory network
por: Gursky, Vitaly V., et al.
Publicado: (2017)

Herpes Simplex Type 1 UL43 Multiple Membrane-Spanning Protein Increases Energy Metabolism in Host Cells through Interacting with ARL2
por: Deng, Jianshan, et al.
Publicado: (2022)

Stochastic Effects in Retrotransposon Dynamics Revealed by Modeling under Competition for Cellular Resources
por: Pavlov, Sergey, et al.
Publicado: (2021)

Correction: pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread
por: Benedyk, Tomasz H., et al.
Publicado: (2022)

Exploring the universe: Festschrift Giacconi (Riccardo)
por: Gursky, Herbert, et al.
Publicado: (2000)

Synergy between serum amyloid A and secretory phospholipase A(2)
por: Jayaraman, Shobini, et al.
Publicado: (2019)

Changes in Representation of Thalamic Projection Neurons within Prefrontal-Thalamic-Hippocampal Circuitry in a Rat Model of Third Trimester Binge Drinking
por: Gursky, Zachary H., et al.
Publicado: (2021)

Characteristics of Artificial Virus-like Particles Assembled in vitro from Potato Virus X Coat Protein and Foreign Viral RNAs
por: Arkhipenko, M.V., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_t3u4tv3fg2jb8fm0v3t2i8vr7l