Cargando…
Enantioselective Total Syntheses of FR901464 and Spliceostatin A and Evaluation of Splicing Activity of Key Derivatives
[Image: see text] FR901464 (1) and spliceostatin A (2) are potent inhibitors of spliceosomes. These compounds have shown remarkable anticancer activity against multiple human cancer cell lines. Herein, we describe efficient, enantioselective syntheses of FR901464, spliceostatin A, six corresponding...
Autores principales: | Ghosh, Arun K., Chen, Zhi-Hua, Effenberger, Kerstin A., Jurica, Melissa S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066912/ https://www.ncbi.nlm.nih.gov/pubmed/24873648 http://dx.doi.org/10.1021/jo500800k |
Ejemplares similares
-
Enantioselective Synthesis of Spliceostatin E and
Evaluation of Biological Activity
por: Ghosh, Arun K., et al.
Publicado: (2014) -
Splicing modulator FR901464 is a potential agent for colorectal cancer in combination therapy
por: Yamano, Tomoki, et al.
Publicado: (2019) -
Synthesis and
Conformational Analysis of FR901464-Based
RNA Splicing Modulators and Their Synergism in Drug-Resistant Cancers
por: Beard, Jacob P., et al.
Publicado: (2023) -
Syntheses of spliceostatins and thailanstatins: a review
por: Donaldson, William A
Publicado: (2020) -
Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation
por: Roybal, Gabriel A., et al.
Publicado: (2010)