Cargando…

Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly

Aims. Elevated pulse pressure (PP) has been reported to be a risk factor for type 2 diabetes in elderly patients with hypertension. Methods. Cross-sectional relationships of PP with known risk factors for type 2 diabetes and inflammatory markers were examined in 150 elderly community-dwelling women,...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamada, Eriko, Takeuchi, Mika, Kurata, Miki, Kazumi, Tsutomu, Fukuo, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066939/
https://www.ncbi.nlm.nih.gov/pubmed/25105150
http://dx.doi.org/10.1155/2014/972431
_version_ 1782322239564152832
author Yamada, Eriko
Takeuchi, Mika
Kurata, Miki
Kazumi, Tsutomu
Fukuo, Keisuke
author_facet Yamada, Eriko
Takeuchi, Mika
Kurata, Miki
Kazumi, Tsutomu
Fukuo, Keisuke
author_sort Yamada, Eriko
collection PubMed
description Aims. Elevated pulse pressure (PP) has been reported to be a risk factor for type 2 diabetes in elderly patients with hypertension. Methods. Cross-sectional relationships of PP with known risk factors for type 2 diabetes and inflammatory markers were examined in 150 elderly community-dwelling women, 79 women (52.7%) of whom had hypertension. Results. Systolic blood pressure (standardized β, 0.775), log tumor necrosis factor-α (TNF-α, standardized β, 0.110), age (standardized β, 0.140), and neutrophil count (standardized β, 0.114) emerged as determinants of PP independent of high-sensitivity C-reactive protein, interleukin-6, monocyte count, plasminogen activator inhibitor-1, homeostasis model assessment of insulin resistance, HDL-cholesterol, and adiponectin (R (2) = 0.772). Conclusions. The present studies have demonstrated an independent association of higher PP with higher TNF-α, a marker of insulin resistance, and neutrophil count in community-living elderly women and suggest that insulin resistance and chronic low-grade inflammation may in part be responsible for the association between high PP and incident type 2 diabetes found in elderly patients with hypertension.
format Online
Article
Text
id pubmed-4066939
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-40669392014-08-07 Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly Yamada, Eriko Takeuchi, Mika Kurata, Miki Kazumi, Tsutomu Fukuo, Keisuke J Diabetes Res Research Article Aims. Elevated pulse pressure (PP) has been reported to be a risk factor for type 2 diabetes in elderly patients with hypertension. Methods. Cross-sectional relationships of PP with known risk factors for type 2 diabetes and inflammatory markers were examined in 150 elderly community-dwelling women, 79 women (52.7%) of whom had hypertension. Results. Systolic blood pressure (standardized β, 0.775), log tumor necrosis factor-α (TNF-α, standardized β, 0.110), age (standardized β, 0.140), and neutrophil count (standardized β, 0.114) emerged as determinants of PP independent of high-sensitivity C-reactive protein, interleukin-6, monocyte count, plasminogen activator inhibitor-1, homeostasis model assessment of insulin resistance, HDL-cholesterol, and adiponectin (R (2) = 0.772). Conclusions. The present studies have demonstrated an independent association of higher PP with higher TNF-α, a marker of insulin resistance, and neutrophil count in community-living elderly women and suggest that insulin resistance and chronic low-grade inflammation may in part be responsible for the association between high PP and incident type 2 diabetes found in elderly patients with hypertension. Hindawi Publishing Corporation 2014 2014-05-27 /pmc/articles/PMC4066939/ /pubmed/25105150 http://dx.doi.org/10.1155/2014/972431 Text en Copyright © 2014 Eriko Yamada et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yamada, Eriko
Takeuchi, Mika
Kurata, Miki
Kazumi, Tsutomu
Fukuo, Keisuke
Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly
title Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly
title_full Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly
title_fullStr Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly
title_full_unstemmed Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly
title_short Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly
title_sort association of pulse pressure with serum tnf-α and neutrophil count in the elderly
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066939/
https://www.ncbi.nlm.nih.gov/pubmed/25105150
http://dx.doi.org/10.1155/2014/972431
work_keys_str_mv AT yamadaeriko associationofpulsepressurewithserumtnfaandneutrophilcountintheelderly
AT takeuchimika associationofpulsepressurewithserumtnfaandneutrophilcountintheelderly
AT kuratamiki associationofpulsepressurewithserumtnfaandneutrophilcountintheelderly
AT kazumitsutomu associationofpulsepressurewithserumtnfaandneutrophilcountintheelderly
AT fukuokeisuke associationofpulsepressurewithserumtnfaandneutrophilcountintheelderly