Role of metal ions in the cognitive decline of Down syndrome

Down syndrome (DS), caused by trisomy of whole or part of chromosome 21 is the most common mental impairment. All people with DS suffer from cognitive decline and develop Alzheimer’s disease (AD) by the age of 40. The appearance of enlarged early endosomes, followed by Amyloid βpeptide deposition, t...

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Autores principales: Malakooti, Nakisa, Pritchard, Melanie A., Adlard, Paul A., Finkelstein, David I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066992/
https://www.ncbi.nlm.nih.gov/pubmed/25002847
http://dx.doi.org/10.3389/fnagi.2014.00136
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author Malakooti, Nakisa
Pritchard, Melanie A.
Adlard, Paul A.
Finkelstein, David I.
author_facet Malakooti, Nakisa
Pritchard, Melanie A.
Adlard, Paul A.
Finkelstein, David I.
author_sort Malakooti, Nakisa
collection PubMed
description Down syndrome (DS), caused by trisomy of whole or part of chromosome 21 is the most common mental impairment. All people with DS suffer from cognitive decline and develop Alzheimer’s disease (AD) by the age of 40. The appearance of enlarged early endosomes, followed by Amyloid βpeptide deposition, the appearance of tau-containing neurofibrillary tangles and basal forebrain cholinergic neuron (BFCN) degeneration are the neuropathological characteristics of this disease. In this review we will examine the role of metal ion dyshomeostasis and the genes which may be involved in these processes, and relate these back to the manifestation of age-dependent cognitive decline in DS.
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spelling pubmed-40669922014-07-07 Role of metal ions in the cognitive decline of Down syndrome Malakooti, Nakisa Pritchard, Melanie A. Adlard, Paul A. Finkelstein, David I. Front Aging Neurosci Neuroscience Down syndrome (DS), caused by trisomy of whole or part of chromosome 21 is the most common mental impairment. All people with DS suffer from cognitive decline and develop Alzheimer’s disease (AD) by the age of 40. The appearance of enlarged early endosomes, followed by Amyloid βpeptide deposition, the appearance of tau-containing neurofibrillary tangles and basal forebrain cholinergic neuron (BFCN) degeneration are the neuropathological characteristics of this disease. In this review we will examine the role of metal ion dyshomeostasis and the genes which may be involved in these processes, and relate these back to the manifestation of age-dependent cognitive decline in DS. Frontiers Media S.A. 2014-06-23 /pmc/articles/PMC4066992/ /pubmed/25002847 http://dx.doi.org/10.3389/fnagi.2014.00136 Text en Copyright © 2014 Malakooti, Pritchard, Adlard and Finkelstein. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Malakooti, Nakisa
Pritchard, Melanie A.
Adlard, Paul A.
Finkelstein, David I.
Role of metal ions in the cognitive decline of Down syndrome
title Role of metal ions in the cognitive decline of Down syndrome
title_full Role of metal ions in the cognitive decline of Down syndrome
title_fullStr Role of metal ions in the cognitive decline of Down syndrome
title_full_unstemmed Role of metal ions in the cognitive decline of Down syndrome
title_short Role of metal ions in the cognitive decline of Down syndrome
title_sort role of metal ions in the cognitive decline of down syndrome
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066992/
https://www.ncbi.nlm.nih.gov/pubmed/25002847
http://dx.doi.org/10.3389/fnagi.2014.00136
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