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The Autolysis of Human HtrA1 Is Governed by the Redox State of Its N-Terminal Domain
[Image: see text] Human HtrA1 (high-temperature requirement protein A1) belongs to a conserved family of serine proteases involved in protein quality control and cell fate. The homotrimeric ubiquitously expressed protease has chymotrypsin-like specificity and primarily targets hydrophobic stretches...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067144/ https://www.ncbi.nlm.nih.gov/pubmed/24846539 http://dx.doi.org/10.1021/bi401633w |