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Comparative Analysis of the Substrate Specificity of trans- versus cis-Acyltransferases of Assembly Line Polyketide Synthases

[Image: see text] Due to their pivotal role in extender unit selection during polyketide biosynthesis, acyltransferase (AT) domains are important engineering targets. A subset of assembly line polyketide synthases (PKSs) are serviced by discrete, trans-acting ATs. Theoretically, these trans-ATs can...

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Detalles Bibliográficos
Autores principales:	Dunn, Briana J., Watts, Katharine R., Robbins, Thomas, Cane, David E., Khosla, Chaitan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067149/ https://www.ncbi.nlm.nih.gov/pubmed/24871074 http://dx.doi.org/10.1021/bi5004316

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