Autoregressive Higher-Order Hidden Markov Models: Exploiting Local Chromosomal Dependencies in the Analysis of Tumor Expression Profiles

Changes in gene expression programs play a central role in cancer. Chromosomal aberrations such as deletions, duplications and translocations of DNA segments can lead to highly significant positive correlations of gene expression levels of neighboring genes. This should be utilized to improve the an...

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Detalles Bibliográficos
Autores principales: Seifert, Michael, Abou-El-Ardat, Khalil, Friedrich, Betty, Klink, Barbara, Deutsch, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067306/
https://www.ncbi.nlm.nih.gov/pubmed/24955771
http://dx.doi.org/10.1371/journal.pone.0100295

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