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A Novel Mouse Fgfr2 Mutant, Hobbyhorse (hob), Exhibits Complete XY Gonadal Sex Reversal

The secreted molecule fibroblast growth factor 9 (FGF9) plays a critical role in testis determination in the mouse. In embryonic gonadal somatic cells it is required for maintenance of SOX9 expression, a key determinant of Sertoli cell fate. Conditional gene targeting studies have identified FGFR2 a...

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Detalles Bibliográficos
Autores principales:	Siggers, Pam, Carré, Gwenn-Aël, Bogani, Debora, Warr, Nick, Wells, Sara, Hilton, Helen, Esapa, Chris, Hajihosseini, Mohammad K., Greenfield, Andy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067367/ https://www.ncbi.nlm.nih.gov/pubmed/24956260 http://dx.doi.org/10.1371/journal.pone.0100447

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