Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells

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While TRAIL is a promising anticancer agent due to its ability to selectively induce apoptosis in neoplastic cells, many tumors, including pancreatic ductal adenocarcinoma (PDA), display intrinsic resistance, highlighting the need for TRAIL-sensitizing agents. Here we report that TRAIL-induced apopt...

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Detalles Bibliográficos
Autores principales: Zhang, J-S, Herreros-Vilanueva, M, Koenig, A, Deng, Z, de Narvajas, A A-M, Gomez, T S, Meng, X, Bujanda, L, Ellenrieder, V, Li, X K, Kaufmann, S H, Billadeau, D D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067531/
https://www.ncbi.nlm.nih.gov/pubmed/24675460
http://dx.doi.org/10.1038/cddis.2014.102
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