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Opioid and GABA(B) receptors differentially couple to an adenylyl cyclase/protein kinase A downstream effector after chronic morphine treatment
Opioids are intensely addictive, and cessation of their chronic use is associated with a highly aversive withdrawal syndrome. A cellular hallmark of withdrawal is an opioid sensitive protein kinase A-dependent increase in GABA transporter-1 (GAT-1) currents in periaqueductal gray (PAG) neurons. Elev...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067908/ https://www.ncbi.nlm.nih.gov/pubmed/25009497 http://dx.doi.org/10.3389/fphar.2014.00148 |