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LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status

Missense mutations in the Leucine-Rich Repeat protein Kinase 2 (LRRK2) gene are the most common genetic predisposition to develop Parkinson’s disease (PD) (Farrer et al., 2005; Skipper et al., 2005; Di Fonzo et al., 2006; Healy et al., 2008; Paisan-Ruiz et al., 2008; Lesage et al., 2010). LRRK2 is a...

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Detalles Bibliográficos
Autores principales:	Reynolds, April, Doggett, Elizabeth A., Riddle, Steve M., Lebakken, Connie S., Nichols, R. Jeremy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068021/ https://www.ncbi.nlm.nih.gov/pubmed/25009464 http://dx.doi.org/10.3389/fnmol.2014.00054

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