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Cubic and Hexagonal Liquid Crystals as Drug Delivery Systems
Lipids have been widely used as main constituents in various drug delivery systems, such as liposomes, solid lipid nanoparticles, nanostructured lipid carriers, and lipid-based lyotropic liquid crystals. Among them, lipid-based lyotropic liquid crystals have highly ordered, thermodynamically stable...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068036/ https://www.ncbi.nlm.nih.gov/pubmed/24995330 http://dx.doi.org/10.1155/2014/815981 |
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author | Chen, Yulin Ma, Ping Gui, Shuangying |
author_facet | Chen, Yulin Ma, Ping Gui, Shuangying |
author_sort | Chen, Yulin |
collection | PubMed |
description | Lipids have been widely used as main constituents in various drug delivery systems, such as liposomes, solid lipid nanoparticles, nanostructured lipid carriers, and lipid-based lyotropic liquid crystals. Among them, lipid-based lyotropic liquid crystals have highly ordered, thermodynamically stable internal nanostructure, thereby offering the potential as a sustained drug release matrix. The intricate nanostructures of the cubic phase and hexagonal phase have been shown to provide diffusion controlled release of active pharmaceutical ingredients with a wide range of molecular weights and polarities. In addition, the biodegradable and biocompatible nature of lipids demonstrates the minimum toxicity and thus they are used for various routes of administration. Therefore, the research on lipid-based lyotropic liquid crystalline phases has attracted a lot of attention in recent years. This review will provide an overview of the lipids used to prepare cubic phase and hexagonal phase at physiological temperature, as well as the influencing factors on the phase transition of liquid crystals. In particular, the most current research progresses on cubic and hexagonal phases as drug delivery systems will be discussed. |
format | Online Article Text |
id | pubmed-4068036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40680362014-07-03 Cubic and Hexagonal Liquid Crystals as Drug Delivery Systems Chen, Yulin Ma, Ping Gui, Shuangying Biomed Res Int Review Article Lipids have been widely used as main constituents in various drug delivery systems, such as liposomes, solid lipid nanoparticles, nanostructured lipid carriers, and lipid-based lyotropic liquid crystals. Among them, lipid-based lyotropic liquid crystals have highly ordered, thermodynamically stable internal nanostructure, thereby offering the potential as a sustained drug release matrix. The intricate nanostructures of the cubic phase and hexagonal phase have been shown to provide diffusion controlled release of active pharmaceutical ingredients with a wide range of molecular weights and polarities. In addition, the biodegradable and biocompatible nature of lipids demonstrates the minimum toxicity and thus they are used for various routes of administration. Therefore, the research on lipid-based lyotropic liquid crystalline phases has attracted a lot of attention in recent years. This review will provide an overview of the lipids used to prepare cubic phase and hexagonal phase at physiological temperature, as well as the influencing factors on the phase transition of liquid crystals. In particular, the most current research progresses on cubic and hexagonal phases as drug delivery systems will be discussed. Hindawi Publishing Corporation 2014 2014-06-05 /pmc/articles/PMC4068036/ /pubmed/24995330 http://dx.doi.org/10.1155/2014/815981 Text en Copyright © 2014 Yulin Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Chen, Yulin Ma, Ping Gui, Shuangying Cubic and Hexagonal Liquid Crystals as Drug Delivery Systems |
title | Cubic and Hexagonal Liquid Crystals as Drug Delivery Systems |
title_full | Cubic and Hexagonal Liquid Crystals as Drug Delivery Systems |
title_fullStr | Cubic and Hexagonal Liquid Crystals as Drug Delivery Systems |
title_full_unstemmed | Cubic and Hexagonal Liquid Crystals as Drug Delivery Systems |
title_short | Cubic and Hexagonal Liquid Crystals as Drug Delivery Systems |
title_sort | cubic and hexagonal liquid crystals as drug delivery systems |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068036/ https://www.ncbi.nlm.nih.gov/pubmed/24995330 http://dx.doi.org/10.1155/2014/815981 |
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