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Posterior AD-Type Pathology: Cognitive Subtypes Emerging from a Cluster Analysis
Background. “Posterior shift” of the neuropathological changes of Alzheimer's disease (AD) produces a syndrome (posterior cortical atrophy) (PCA) dominated by high-level visual deficits. Objective. To explore in patients with AD-type pathology whether a data-driven analysis (cluster analysis) b...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068066/ https://www.ncbi.nlm.nih.gov/pubmed/24994944 http://dx.doi.org/10.1155/2014/259358 |
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author | Cappa, Antonella Ciccarelli, Nicoletta Baldonero, Eleonora Martelli, Marialuisa Silveri, Maria Caterina |
author_facet | Cappa, Antonella Ciccarelli, Nicoletta Baldonero, Eleonora Martelli, Marialuisa Silveri, Maria Caterina |
author_sort | Cappa, Antonella |
collection | PubMed |
description | Background. “Posterior shift” of the neuropathological changes of Alzheimer's disease (AD) produces a syndrome (posterior cortical atrophy) (PCA) dominated by high-level visual deficits. Objective. To explore in patients with AD-type pathology whether a data-driven analysis (cluster analysis) based on neuropsychological findings resulted in the emergence of different subgroups of patients; in particular to find out whether it was possible to identify patients with visuospatial deficits consistent with the hypothesis that PCA is a “dorsal stream” syndrome or, rather, whether there were subgroups of patients with different types of impairment within the high-level visual domain. Methods. 23 PCA and 16 DAT patients were studied. By a principal component analysis performed on a wide range of neuropsychological tasks, 15 variables were obtained that loaded onto five main factors (memory, language, perceptual, visuospatial, and calculation) which entered a hierarchical cluster analysis. Results. Four clusters of cognitive impairment emerged: visuospatial/perceptual, memory, perceptual/calculation, and language. Only in the first cluster a visuospatial deficit clearly emerged. Conclusions. AD pathology produces not only variants dominated by memory (DAT) and, to a lesser extent, visuospatial deficit (PCA), but also other distinct syndromic subtypes with disorders in visual perception and language which reflect a different vulnerability of specific functional networks. |
format | Online Article Text |
id | pubmed-4068066 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40680662014-07-03 Posterior AD-Type Pathology: Cognitive Subtypes Emerging from a Cluster Analysis Cappa, Antonella Ciccarelli, Nicoletta Baldonero, Eleonora Martelli, Marialuisa Silveri, Maria Caterina Behav Neurol Research Article Background. “Posterior shift” of the neuropathological changes of Alzheimer's disease (AD) produces a syndrome (posterior cortical atrophy) (PCA) dominated by high-level visual deficits. Objective. To explore in patients with AD-type pathology whether a data-driven analysis (cluster analysis) based on neuropsychological findings resulted in the emergence of different subgroups of patients; in particular to find out whether it was possible to identify patients with visuospatial deficits consistent with the hypothesis that PCA is a “dorsal stream” syndrome or, rather, whether there were subgroups of patients with different types of impairment within the high-level visual domain. Methods. 23 PCA and 16 DAT patients were studied. By a principal component analysis performed on a wide range of neuropsychological tasks, 15 variables were obtained that loaded onto five main factors (memory, language, perceptual, visuospatial, and calculation) which entered a hierarchical cluster analysis. Results. Four clusters of cognitive impairment emerged: visuospatial/perceptual, memory, perceptual/calculation, and language. Only in the first cluster a visuospatial deficit clearly emerged. Conclusions. AD pathology produces not only variants dominated by memory (DAT) and, to a lesser extent, visuospatial deficit (PCA), but also other distinct syndromic subtypes with disorders in visual perception and language which reflect a different vulnerability of specific functional networks. Hindawi Publishing Corporation 2014 2014-06-05 /pmc/articles/PMC4068066/ /pubmed/24994944 http://dx.doi.org/10.1155/2014/259358 Text en Copyright © 2014 Antonella Cappa et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Cappa, Antonella Ciccarelli, Nicoletta Baldonero, Eleonora Martelli, Marialuisa Silveri, Maria Caterina Posterior AD-Type Pathology: Cognitive Subtypes Emerging from a Cluster Analysis |
title | Posterior AD-Type Pathology: Cognitive Subtypes Emerging from a Cluster Analysis |
title_full | Posterior AD-Type Pathology: Cognitive Subtypes Emerging from a Cluster Analysis |
title_fullStr | Posterior AD-Type Pathology: Cognitive Subtypes Emerging from a Cluster Analysis |
title_full_unstemmed | Posterior AD-Type Pathology: Cognitive Subtypes Emerging from a Cluster Analysis |
title_short | Posterior AD-Type Pathology: Cognitive Subtypes Emerging from a Cluster Analysis |
title_sort | posterior ad-type pathology: cognitive subtypes emerging from a cluster analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068066/ https://www.ncbi.nlm.nih.gov/pubmed/24994944 http://dx.doi.org/10.1155/2014/259358 |
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