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Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics
Regions of close apposition between two organelles, often referred to as membrane contact sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle, although contacts between mitochondria and other organelles have also begun to be characterized. Although these contact sites...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Rockefeller University Press
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068136/ https://www.ncbi.nlm.nih.gov/pubmed/24958771 http://dx.doi.org/10.1083/jcb.201401126 |
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author | Prinz, William A. |
author_facet | Prinz, William A. |
author_sort | Prinz, William A. |
collection | PubMed |
description | Regions of close apposition between two organelles, often referred to as membrane contact sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle, although contacts between mitochondria and other organelles have also begun to be characterized. Although these contact sites have been noted since cells first began to be visualized with electron microscopy, the functions of most of these domains long remained unclear. The last few years have witnessed a dramatic increase in our understanding of MCSs, revealing the critical roles they play in intracellular signaling, metabolism, the trafficking of metabolites, and organelle inheritance, division, and transport. |
format | Online Article Text |
id | pubmed-4068136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-40681362014-12-23 Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics Prinz, William A. J Cell Biol Reviews Regions of close apposition between two organelles, often referred to as membrane contact sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle, although contacts between mitochondria and other organelles have also begun to be characterized. Although these contact sites have been noted since cells first began to be visualized with electron microscopy, the functions of most of these domains long remained unclear. The last few years have witnessed a dramatic increase in our understanding of MCSs, revealing the critical roles they play in intracellular signaling, metabolism, the trafficking of metabolites, and organelle inheritance, division, and transport. The Rockefeller University Press 2014-06-23 /pmc/articles/PMC4068136/ /pubmed/24958771 http://dx.doi.org/10.1083/jcb.201401126 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Reviews Prinz, William A. Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics |
title | Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics |
title_full | Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics |
title_fullStr | Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics |
title_full_unstemmed | Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics |
title_short | Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics |
title_sort | bridging the gap: membrane contact sites in signaling, metabolism, and organelle dynamics |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068136/ https://www.ncbi.nlm.nih.gov/pubmed/24958771 http://dx.doi.org/10.1083/jcb.201401126 |
work_keys_str_mv | AT prinzwilliama bridgingthegapmembranecontactsitesinsignalingmetabolismandorganelledynamics |