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Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics

Regions of close apposition between two organelles, often referred to as membrane contact sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle, although contacts between mitochondria and other organelles have also begun to be characterized. Although these contact sites...

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Detalles Bibliográficos
Autor principal: Prinz, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068136/
https://www.ncbi.nlm.nih.gov/pubmed/24958771
http://dx.doi.org/10.1083/jcb.201401126
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author Prinz, William A.
author_facet Prinz, William A.
author_sort Prinz, William A.
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description Regions of close apposition between two organelles, often referred to as membrane contact sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle, although contacts between mitochondria and other organelles have also begun to be characterized. Although these contact sites have been noted since cells first began to be visualized with electron microscopy, the functions of most of these domains long remained unclear. The last few years have witnessed a dramatic increase in our understanding of MCSs, revealing the critical roles they play in intracellular signaling, metabolism, the trafficking of metabolites, and organelle inheritance, division, and transport.
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spelling pubmed-40681362014-12-23 Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics Prinz, William A. J Cell Biol Reviews Regions of close apposition between two organelles, often referred to as membrane contact sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle, although contacts between mitochondria and other organelles have also begun to be characterized. Although these contact sites have been noted since cells first began to be visualized with electron microscopy, the functions of most of these domains long remained unclear. The last few years have witnessed a dramatic increase in our understanding of MCSs, revealing the critical roles they play in intracellular signaling, metabolism, the trafficking of metabolites, and organelle inheritance, division, and transport. The Rockefeller University Press 2014-06-23 /pmc/articles/PMC4068136/ /pubmed/24958771 http://dx.doi.org/10.1083/jcb.201401126 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Prinz, William A.
Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics
title Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics
title_full Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics
title_fullStr Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics
title_full_unstemmed Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics
title_short Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics
title_sort bridging the gap: membrane contact sites in signaling, metabolism, and organelle dynamics
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068136/
https://www.ncbi.nlm.nih.gov/pubmed/24958771
http://dx.doi.org/10.1083/jcb.201401126
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