Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery?

[Image: see text] The ATP site of kinases displays remarkable conformational flexibility when accommodating chemically diverse small molecule inhibitors. The so-called activation segment, whose conformation controls catalytic activity and access to the substrate binding pocket, can undergo a large c...

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Detalles Bibliográficos
Autores principales: Zhao, Zheng, Wu, Hong, Wang, Li, Liu, Yi, Knapp, Stefan, Liu, Qingsong, Gray, Nathanael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068218/
https://www.ncbi.nlm.nih.gov/pubmed/24730530
http://dx.doi.org/10.1021/cb500129t

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