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T-bet is essential for Th1-mediated, but not Th17-mediated, CNS autoimmune disease

T cells that produce both IL-17 and IFN-γ, and co-express ROR-γt and T-bet, are often found at sites of autoimmune inflammation. However, it is unknown whether this co-expression of T-bet with ROR-γt is a prerequisite for immunopathology. We show here that T-bet is not required for the development o...

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Detalles Bibliográficos
Autores principales:	O'Connor, Richard A, Cambrook, Helen, Huettner, Katja, Anderton, Stephen M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2013
Materias:	Highlights
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068221/ https://www.ncbi.nlm.nih.gov/pubmed/23878019 http://dx.doi.org/10.1002/eji.201343689

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