Solution Structure of CCP Modules 10–12 Illuminates Functional Architecture of the Complement Regulator, Factor H

The 155-kDa plasma glycoprotein factor H (FH), which consists of 20 complement control protein (CCP) modules, protects self-tissue but not foreign organisms from damage by the complement cascade. Protection is achieved by selective engagement of FH, via CCPs 1–4, CCPs 6–8 and CCPs 19–20, with polyan...

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Detalles Bibliográficos
Autores principales: Makou, Elisavet, Mertens, Haydyn D.T., Maciejewski, Mateusz, Soares, Dinesh C., Matis, Ilias, Schmidt, Christoph Q., Herbert, Andrew P., Svergun, Dmitri I., Barlow, Paul N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068365/
https://www.ncbi.nlm.nih.gov/pubmed/23017427
http://dx.doi.org/10.1016/j.jmb.2012.09.013

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