Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity

BACKGROUND: Wnt proteins are a family of secreted signaling molecules that regulate key developmental processes in metazoans. The molecular basis of Wnt binding to Frizzled and LRP5/6 co-receptors has long been unknown due to the lack of structural data on Wnt ligands. Only recently, the crystal str...

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Detalles Bibliográficos
Autores principales: Kumar, Sumit, Žigman, Mihaela, Patel, Trushar R, Trageser, Benjamin, Gross, Julia Christina, Rahm, Karolin, Boutros, Michael, Gradl, Dietmar, Steinbeisser, Herbert, Holstein, Thomas, Stetefeld, Jörg, Özbek, Suat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068752/
https://www.ncbi.nlm.nih.gov/pubmed/24885675
http://dx.doi.org/10.1186/1741-7007-12-44

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