The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity

The Wnt receptor Ryk is an evolutionary-conserved protein important during neuronal differentiation through several mechanisms, including γ-secretase cleavage and nuclear translocation of its intracellular domain (Ryk-ICD). Although the Wnt pathway may be neuroprotective, the role of Ryk in neurodeg...

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Detalles Bibliográficos
Autores principales: Tourette, Cendrine, Farina, Francesca, Vazquez-Manrique, Rafael P., Orfila, Anne-Marie, Voisin, Jessica, Hernandez, Sonia, Offner, Nicolas, Parker, J. Alex, Menet, Sophie, Kim, Jinho, Lyu, Jungmok, Choi, Si Ho, Cormier, Kerry, Edgerly, Christina K., Bordiuk, Olivia L., Smith, Karen, Louise, Anne, Halford, Michael, Stacker, Steven, Vert, Jean-Philippe, Ferrante, Robert J., Lu, Wange, Neri, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068980/
https://www.ncbi.nlm.nih.gov/pubmed/24960609
http://dx.doi.org/10.1371/journal.pbio.1001895

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