Efficient Induction of Apoptosis by Wee1 Kinase Inhibition in Hepatocellular Carcinoma Cells

Transforming growth factor-β1 (TGF-β1) potently inhibits human hepatocellular carcinoma (HCC) cell growth. Here we demonstrated that TGF-β1-induced apoptosis is mediated by decreased phosphorylation of cdc2 at Tyr15 accompanied by down-regulation of Wee1 kinase expression. As expected from these res...

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Detalles Bibliográficos
Autores principales: Kogiso, Tomomi, Nagahara, Hikaru, Hashimoto, Etsuko, Ariizumi, Shunichi, Yamamoto, Masakazu, Shiratori, Keiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069002/
https://www.ncbi.nlm.nih.gov/pubmed/24960176
http://dx.doi.org/10.1371/journal.pone.0100495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069002/
https://www.ncbi.nlm.nih.gov/pubmed/24960176
http://dx.doi.org/10.1371/journal.pone.0100495

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