Dengue Type Four Viruses with E-Glu(345)Lys Adaptive Mutation from MRC-5 Cells Induce Low Viremia but Elicit Potent Neutralizing Antibodies in Rhesus Monkeys

Knowledge of virulence and immunogenicity is important for development of live-attenuated dengue vaccines. We previously reported that an infectious clone-derived dengue type 4 virus (DENV-4) passaged in MRC-5 cells acquired a Glu(345)Lys (E-E(345)K) substitution in the E protein domain III (E-DIII)...

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Detalles Bibliográficos
Autores principales: Lin, Hsiao-Han, Lee, Hsiang-Chi, Li, Xiao-Feng, Tsai, Meng-Ju, Hsiao, Hung-Ju, Peng, Jia-Guan, Sue, Shih-Che, Qin, Cheng-Feng, Wu, Suh-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069063/
https://www.ncbi.nlm.nih.gov/pubmed/24959738
http://dx.doi.org/10.1371/journal.pone.0100130

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