Cargando…

Caffeic Acid Derivatives Inhibit the Growth of Colon Cancer: Involvement of the PI3-K/Akt and AMPK Signaling Pathways

BACKGROUND: The aberrant regulation of phosphatidylinositide 3-kinases (PI3-K)/Akt, AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (m-TOR) signaling pathways in cancer has prompted significant interest in the suppression of these pathways to treat cancer. Caffeic acid (CA) has...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chiang, En-Pei Isabel, Tsai, Shu-Yao, Kuo, Yueh-Hsiung, Pai, Man-Hui, Chiu, Hsi-Lin, Rodriguez, Raymond L., Tang, Feng-Yao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069067/ https://www.ncbi.nlm.nih.gov/pubmed/24960186 http://dx.doi.org/10.1371/journal.pone.0099631

Ejemplares similares

Decyl caffeic acid inhibits the proliferation of colorectal cancer cells in an autophagy-dependent manner in vitro and in vivo
por: Chen, Ching, et al.
Publicado: (2020)

Caffeic acid phenethyl amide ameliorates ischemia/reperfusion injury and cardiac dysfunction in streptozotocin-induced diabetic rats
por: Ho, Yi-Jin, et al.
Publicado: (2014)

Modification of Caffeic Acid with Pyrrolidine Enhances Antioxidant Ability by Activating AKT/HO-1 Pathway in Heart
por: Ku, Hui-Chun, et al.
Publicado: (2016)

Pyrrolidinyl caffeamide against ischemia/reperfusion injury in cardiomyocytes through AMPK/AKT pathways
por: Lee, Shih-Yi, et al.
Publicado: (2015)

Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin
por: Weng, Yi-Chun, et al.
Publicado: (2012)

Caffeic acid phenethyl amide improves glucose homeostasis and attenuates the progression of vascular dysfunction in Streptozotocin-induced diabetic rats
por: Ho, Yi-Jin, et al.
Publicado: (2013)

Caffeic acid ethanolamide prevents cardiac dysfunction through sirtuin dependent cardiac bioenergetics preservation
por: Lee, Shih-Yi, et al.
Publicado: (2015)

Regulatory Effects of Caffeic Acid Phenethyl Ester on Neuroinflammation in Microglial Cells
por: Tsai, Cheng-Fang, et al.
Publicado: (2015)

Inotilone from Inonotus linteus suppresses lung cancer metastasis in vitro and in vivo through ROS-mediated PI3K/AKT/MAPK signaling pathways
por: Chao, Wei, et al.
Publicado: (2019)

Caffeic Acid Phenethyl Ester and Caffeamide Derivatives Suppress Oral Squamous Cell Carcinoma Cells
por: Shih, Yin-Hwa, et al.
Publicado: (2023)

Antidiabetic Effect of Artemether in Db/Db Mice Involves Regulation of AMPK and PI3K/Akt Pathways
por: Bai, Xiaolin, et al.
Publicado: (2020)

A Novel Therapeutic Approach for Colorectal Cancer Stem Cells: Blocking the PI3K/Akt Signaling Axis With Caffeic Acid
por: Park, Se-Ra, et al.
Publicado: (2020)

Protective Effect of Caffeic Acid Derivatives on tert-Butyl Hydroperoxide-Induced Oxidative Hepato-Toxicity and Mitochondrial Dysfunction in HepG2 Cells
por: Tsai, Tzung-Hsun, et al.
Publicado: (2017)

Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way
por: En, Qiao, et al.
Publicado: (2021)

Role of AMPK and Akt in triple negative breast cancer lung colonization
por: Johnson, Jeremy, et al.
Publicado: (2021)

Metformin triggers the intrinsic apoptotic response in human AGS gastric adenocarcinoma cells by activating AMPK and suppressing mTOR/AKT signaling
por: Lu, Chi-Cheng, et al.
Publicado: (2019)

Differential crosstalk between the AMPK and PI3K/Akt pathways in breast cancer cells of differing genotypes: Leptin inhibits the effectiveness of AMPK activation
por: EL-MASRY, OMAR S., et al.
Publicado: (2015)

Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites
por: Tang, Hao, et al.
Publicado: (2017)

N-Octyl Caffeamide, a Caffeic Acid Amide Derivative, Prevents Progression of Diabetes and Hepatic Steatosis in High-Fat Diet Induced Obese Mice
por: Wu, Miao-Yi, et al.
Publicado: (2022)

Caffeic Acid Phenethyl Ester as a Potential Treatment for Advanced Prostate Cancer Targeting Akt Signaling
por: Lin, Hui-Ping, et al.
Publicado: (2013)

Caffeic and Chlorogenic Acids Synergistically Activate Browning Program in Human Adipocytes: Implications of AMPK- and PPAR-Mediated Pathways
por: Vasileva, Liliya V., et al.
Publicado: (2020)

RSC96 Schwann Cell Proliferation and Survival Induced by Dilong through PI3K/Akt Signaling Mediated by IGF-I
por: Chang, Yung-Ming, et al.
Publicado: (2011)

Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways
por: Mazibuko-Mbeje, Sithandiwe E., et al.
Publicado: (2019)

The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways
por: Chen, Xubo, et al.
Publicado: (2017)

Asiatic acid attenuates hypertrophic and fibrotic differentiation of articular chondrocytes via AMPK/PI3K/AKT signaling pathway
por: Liu, Na, et al.
Publicado: (2020)

Metformin induces apoptosis and inhibits migration by activating the AMPK/p53 axis and suppressing PI3K/AKT signaling in human cervical cancer cells
por: Chen, Ya-Hui, et al.
Publicado: (2021)

Caffeic Acid Phenethyl Ester Suppresses Proliferation and Survival of TW2.6 Human Oral Cancer Cells via Inhibition of Akt Signaling
por: Kuo, Ying-Yu, et al.
Publicado: (2013)

Swimming exercise stimulates IGF1/ PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus
por: Lin, Jing-Ying, et al.
Publicado: (2020)

Sinensol-C Isolated from Spiranthes sinensis Inhibits Adipogenesis in 3T3-L1 Cells through the Regulation of Adipogenic Transcription Factors and AMPK Activation
por: Shie, Pei-Hsin, et al.
Publicado: (2020)

Activation of the PI3K/AKT pathway correlates with prognosis in stage II colon cancer
por: Malinowsky, K, et al.
Publicado: (2014)

Quercetin ameliorates chicken quality by activating the PI3K/PKB/AMPK signaling pathway in broilers
por: Wang, Mi, et al.
Publicado: (2022)

AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer
por: Choudhury, Yashmin, et al.
Publicado: (2014)

The protective effects of maltol on cisplatin-induced nephrotoxicity through the AMPK-mediated PI3K/Akt and p53 signaling pathways
por: Mi, Xiao-jie, et al.
Publicado: (2018)

Proteome Analysis of USP7 Substrates Revealed Its Role in Melanoma Through PI3K/Akt/FOXO and AMPK Pathways
por: Gao, Lanyang, et al.
Publicado: (2021)

Curcumin (CUMINUP60®) mitigates exercise fatigue through regulating PI3K/Akt/AMPK/mTOR pathway in mice
por: Hu, Minghui, et al.
Publicado: (2023)

Myricetin induces apoptosis and autophagy by inhibiting PI3K/Akt/mTOR signalling in human colon cancer cells
por: Zhu, Ming-liang, et al.
Publicado: (2020)

Ursolic Acid-Induced Apoptosis via Regulation of the PI3K/Akt and MAPK Signaling Pathways in Huh-7 Cells
por: Lee, Kwong-Chiu, et al.
Publicado: (2018)

Correction for: Swimming exercise stimulates IGF1/PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus
por: Lin, Jing-Ying, et al.
Publicado: (2020)

Caffeamide 36-13 Regulates the Antidiabetic and Hypolipidemic Signs of High-Fat-Fed Mice on Glucose Transporter 4, AMPK Phosphorylation, and Regulated Hepatic Glucose Production
por: Kuo, Yueh-Hsiung, et al.
Publicado: (2014)

PI3K/Akt and HIF-1 signaling pathway in hypoxia-ischemia
por: Zhang, Zhen, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9b6e7tmnu2sf95fa7vcl7r6gq2