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Computational Design of a pH Stable Enzyme: Understanding Molecular Mechanism of Penicillin Acylase's Adaptation to Alkaline Conditions

Protein stability provides advantageous development of novel properties and can be crucial in affording tolerance to mutations that introduce functionally preferential phenotypes. Consequently, understanding the determining factors for protein stability is important for the study of structure-functi...

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Detalles Bibliográficos
Autores principales:	Suplatov, Dmitry, Panin, Nikolay, Kirilin, Evgeny, Shcherbakova, Tatyana, Kudryavtsev, Pavel, Švedas, Vytas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069103/ https://www.ncbi.nlm.nih.gov/pubmed/24959852 http://dx.doi.org/10.1371/journal.pone.0100643

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