Nanosizing of a poorly soluble drug: technique optimization, factorial analysis, and pharmacokinetic study in healthy human volunteers

CONTEXT: Diacerein (DCN) has low aqueous solubility (3.197 mg/L) and, consequently, low oral bioavailability (35%–56%). To increase both the solubility and dissolution rate of DCN while maintaining its crystalline nature, high pressure homogenization was used but with only a few homogenization cycle...

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Detalles Bibliográficos
Autores principales: Elsayed, Ibrahim, Abdelbary, Aly Ahmed, Elshafeey, Ahmed Hassen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069131/
https://www.ncbi.nlm.nih.gov/pubmed/24971006
http://dx.doi.org/10.2147/IJN.S63395

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