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Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma
PURPOSE: To evaluate the effects of bimatoprost 0.03% single treatment for 3 years on intraocular pressure (IOP) and visual field performance. METHODS: We monitored the IOP of 62 patients with normal-tension glaucoma every 1–3 months. The Humphrey visual field test was performed every 6 months after...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069150/ https://www.ncbi.nlm.nih.gov/pubmed/24970996 http://dx.doi.org/10.2147/OPTH.S60538 |
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author | Inoue, Kenji Shiokawa, Minako Fujimoto, Takayuki Tomita, Goji |
author_facet | Inoue, Kenji Shiokawa, Minako Fujimoto, Takayuki Tomita, Goji |
author_sort | Inoue, Kenji |
collection | PubMed |
description | PURPOSE: To evaluate the effects of bimatoprost 0.03% single treatment for 3 years on intraocular pressure (IOP) and visual field performance. METHODS: We monitored the IOP of 62 patients with normal-tension glaucoma every 1–3 months. The Humphrey visual field test was performed every 6 months after treatment and the results obtained were compared to those before treatment. In addition, visual field performance was evaluated using trend and event analysis. RESULTS: The mean ± standard deviation (SD) of IOP after treatment with bimatoprost for 3 years (13.6±3.1 mmHg) was significantly lower than that before treatment (16.8±2.4 mmHg, P<0.0001). No change was observed in the mean deviation and pattern SD values of the Humphrey visual field before and 3 years after treatment. Worsening of visual field performance was observed in one patient (3.0%) by using trend analysis and in four patients (12.1%) by using event analysis. Treatment was discontinued in 17 patients (27.4%) because of adverse reactions. CONCLUSION: Bimatoprost 0.03% single treatment was effective in reducing the IOP at least during the 3 years of treatment, but visual field performance worsened by 3.0%–12.1% in patients with normal-tension glaucoma. |
format | Online Article Text |
id | pubmed-4069150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-40691502014-06-26 Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma Inoue, Kenji Shiokawa, Minako Fujimoto, Takayuki Tomita, Goji Clin Ophthalmol Original Research PURPOSE: To evaluate the effects of bimatoprost 0.03% single treatment for 3 years on intraocular pressure (IOP) and visual field performance. METHODS: We monitored the IOP of 62 patients with normal-tension glaucoma every 1–3 months. The Humphrey visual field test was performed every 6 months after treatment and the results obtained were compared to those before treatment. In addition, visual field performance was evaluated using trend and event analysis. RESULTS: The mean ± standard deviation (SD) of IOP after treatment with bimatoprost for 3 years (13.6±3.1 mmHg) was significantly lower than that before treatment (16.8±2.4 mmHg, P<0.0001). No change was observed in the mean deviation and pattern SD values of the Humphrey visual field before and 3 years after treatment. Worsening of visual field performance was observed in one patient (3.0%) by using trend analysis and in four patients (12.1%) by using event analysis. Treatment was discontinued in 17 patients (27.4%) because of adverse reactions. CONCLUSION: Bimatoprost 0.03% single treatment was effective in reducing the IOP at least during the 3 years of treatment, but visual field performance worsened by 3.0%–12.1% in patients with normal-tension glaucoma. Dove Medical Press 2014-06-19 /pmc/articles/PMC4069150/ /pubmed/24970996 http://dx.doi.org/10.2147/OPTH.S60538 Text en © 2014 Inoue et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Inoue, Kenji Shiokawa, Minako Fujimoto, Takayuki Tomita, Goji Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma |
title | Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma |
title_full | Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma |
title_fullStr | Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma |
title_full_unstemmed | Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma |
title_short | Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma |
title_sort | effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069150/ https://www.ncbi.nlm.nih.gov/pubmed/24970996 http://dx.doi.org/10.2147/OPTH.S60538 |
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