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Differences in the Known Cellular Composition of Benign Pigmented Skin Lesions Reflected in Computer-Aided Image Analysis
BACKGROUND: Computer-aided image analysis (CAIA) has been suggested as an effective diagnostic tool for pigmented skin lesions (PSLs), especially melanoma. However, few studies on benign PSLs have been reported. OBJECTIVE: The purpose of this study was to evaluate benign PSLs with our CAIA software...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Dermatological Association; The Korean Society for Investigative Dermatology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069641/ https://www.ncbi.nlm.nih.gov/pubmed/24966630 http://dx.doi.org/10.5021/ad.2014.26.3.314 |
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author | Choi, Jae Woo Ryu, Hyeong Ho Byun, Sang Young Youn, Sang Woong |
author_facet | Choi, Jae Woo Ryu, Hyeong Ho Byun, Sang Young Youn, Sang Woong |
author_sort | Choi, Jae Woo |
collection | PubMed |
description | BACKGROUND: Computer-aided image analysis (CAIA) has been suggested as an effective diagnostic tool for pigmented skin lesions (PSLs), especially melanoma. However, few studies on benign PSLs have been reported. OBJECTIVE: The purpose of this study was to evaluate benign PSLs with our CAIA software and analyze the differences between the parameters of those lesions. METHODS: By using homegrown CAIA software, we analyzed 3 kinds of PSLs-nevus, lentigo, and seborrheic keratosis. The group of seborrheic keratosis was divided into pigmented seborrheic keratosis, sebolentigine, and hyperkeratotic seborrheic keratosis. The CAIA was used to extract the color, as well as the morphological, textural, and topological features from each image. RESULTS: In line with clinical observations, the objective parameters indicated that nevus was dark and round, lentigo was small and bright, and seborrheic keratosis was large and spiky. The surface of nevus showed the highest contrast and correlation. In topological analysis, the concentricity clearly separated melanocytic lesions from seborrheic keratosis. The parameters of pigmented seborrheic keratosis were between those of typical nevus and seborrheic keratosis. CONCLUSION: We confirmed that definite correlations exist between the subjective differentiation by experts' examination and the objective evaluation by using CAIA. We also found that the morphological differences observed in CAIA were greatly influenced by the composition ratios of keratinocytes and melanocytes, which are already known histopathological characteristics of each PSL. |
format | Online Article Text |
id | pubmed-4069641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Korean Dermatological Association; The Korean Society for Investigative Dermatology |
record_format | MEDLINE/PubMed |
spelling | pubmed-40696412014-06-25 Differences in the Known Cellular Composition of Benign Pigmented Skin Lesions Reflected in Computer-Aided Image Analysis Choi, Jae Woo Ryu, Hyeong Ho Byun, Sang Young Youn, Sang Woong Ann Dermatol Original Article BACKGROUND: Computer-aided image analysis (CAIA) has been suggested as an effective diagnostic tool for pigmented skin lesions (PSLs), especially melanoma. However, few studies on benign PSLs have been reported. OBJECTIVE: The purpose of this study was to evaluate benign PSLs with our CAIA software and analyze the differences between the parameters of those lesions. METHODS: By using homegrown CAIA software, we analyzed 3 kinds of PSLs-nevus, lentigo, and seborrheic keratosis. The group of seborrheic keratosis was divided into pigmented seborrheic keratosis, sebolentigine, and hyperkeratotic seborrheic keratosis. The CAIA was used to extract the color, as well as the morphological, textural, and topological features from each image. RESULTS: In line with clinical observations, the objective parameters indicated that nevus was dark and round, lentigo was small and bright, and seborrheic keratosis was large and spiky. The surface of nevus showed the highest contrast and correlation. In topological analysis, the concentricity clearly separated melanocytic lesions from seborrheic keratosis. The parameters of pigmented seborrheic keratosis were between those of typical nevus and seborrheic keratosis. CONCLUSION: We confirmed that definite correlations exist between the subjective differentiation by experts' examination and the objective evaluation by using CAIA. We also found that the morphological differences observed in CAIA were greatly influenced by the composition ratios of keratinocytes and melanocytes, which are already known histopathological characteristics of each PSL. Korean Dermatological Association; The Korean Society for Investigative Dermatology 2014-06 2014-06-12 /pmc/articles/PMC4069641/ /pubmed/24966630 http://dx.doi.org/10.5021/ad.2014.26.3.314 Text en Copyright © 2014 The Korean Dermatological Association and The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Choi, Jae Woo Ryu, Hyeong Ho Byun, Sang Young Youn, Sang Woong Differences in the Known Cellular Composition of Benign Pigmented Skin Lesions Reflected in Computer-Aided Image Analysis |
title | Differences in the Known Cellular Composition of Benign Pigmented Skin Lesions Reflected in Computer-Aided Image Analysis |
title_full | Differences in the Known Cellular Composition of Benign Pigmented Skin Lesions Reflected in Computer-Aided Image Analysis |
title_fullStr | Differences in the Known Cellular Composition of Benign Pigmented Skin Lesions Reflected in Computer-Aided Image Analysis |
title_full_unstemmed | Differences in the Known Cellular Composition of Benign Pigmented Skin Lesions Reflected in Computer-Aided Image Analysis |
title_short | Differences in the Known Cellular Composition of Benign Pigmented Skin Lesions Reflected in Computer-Aided Image Analysis |
title_sort | differences in the known cellular composition of benign pigmented skin lesions reflected in computer-aided image analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069641/ https://www.ncbi.nlm.nih.gov/pubmed/24966630 http://dx.doi.org/10.5021/ad.2014.26.3.314 |
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