Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6...

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Autores principales: Rogers, G. B., Kozlowska, J., Keeble, J., Metcalfe, K., Fao, M., Dowd, S. E., Mason, A. J., McGuckin, M. A., Bruce, K. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069701/
https://www.ncbi.nlm.nih.gov/pubmed/24961643
http://dx.doi.org/10.1038/srep05437
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author Rogers, G. B.
Kozlowska, J.
Keeble, J.
Metcalfe, K.
Fao, M.
Dowd, S. E.
Mason, A. J.
McGuckin, M. A.
Bruce, K. D.
author_facet Rogers, G. B.
Kozlowska, J.
Keeble, J.
Metcalfe, K.
Fao, M.
Dowd, S. E.
Mason, A. J.
McGuckin, M. A.
Bruce, K. D.
author_sort Rogers, G. B.
collection PubMed
description Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.
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spelling pubmed-40697012014-08-27 Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice Rogers, G. B. Kozlowska, J. Keeble, J. Metcalfe, K. Fao, M. Dowd, S. E. Mason, A. J. McGuckin, M. A. Bruce, K. D. Sci Rep Article Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models. Nature Publishing Group 2014-06-25 /pmc/articles/PMC4069701/ /pubmed/24961643 http://dx.doi.org/10.1038/srep05437 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Article
Rogers, G. B.
Kozlowska, J.
Keeble, J.
Metcalfe, K.
Fao, M.
Dowd, S. E.
Mason, A. J.
McGuckin, M. A.
Bruce, K. D.
Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice
title Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice
title_full Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice
title_fullStr Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice
title_full_unstemmed Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice
title_short Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice
title_sort functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069701/
https://www.ncbi.nlm.nih.gov/pubmed/24961643
http://dx.doi.org/10.1038/srep05437
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