Regulation of O(2) consumption by the PI3K and mTOR pathways contributes to tumor hypoxia

BACKGROUND: Inhibitors of the phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) pathway are currently in clinical trials. In addition to antiproliferative and proapoptotic effects, these agents also diminish tumor hypoxia. Since hypoxia is a major cause of resistance...

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Detalles Bibliográficos
Autores principales: Kelly, Catherine J., Hussien, Kamila, Fokas, Emmanouil, Kannan, Pavitra, Shipley, Rebecca J., Ashton, Thomas M., Stratford, Michael, Pearson, Natalie, Muschel, Ruth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Scientific Publishers 2014
Materias:
Molecular Radiobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070024/
https://www.ncbi.nlm.nih.gov/pubmed/24631147
http://dx.doi.org/10.1016/j.radonc.2014.02.007

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