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Attenuation and Immunogenicity of a Live High Pathogenic PRRSV Vaccine Candidate with a 32-Amino Acid Deletion in the nsp2 Protein

A porcine reproductive and respiratory syndrome virus (PRRSV) QY1 was serially passed on Marc-145 cells. Virulence of different intermediate derivatives of QY1 (P5, P60, P80, and P100) were determined. The study found that QY1 had been gradually attenuated during the in vitro process. Pathogenicity...

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Detalles Bibliográficos
Autores principales:	Lu, Wenhui, Sun, Baoli, Mo, Jianyue, Zeng, Xiduo, Zhang, Guanqun, Wang, Lianxiang, Zhou, Qingfeng, Zhu, Ling, Li, Zhili, Xie, Qingmei, Bi, Yinzuo, Ma, Jingyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070328/ https://www.ncbi.nlm.nih.gov/pubmed/25009824 http://dx.doi.org/10.1155/2014/810523

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