Wilson Disease Protein ATP7B Utilizes Lysosomal Exocytosis to Maintain Copper Homeostasis

Copper is an essential yet toxic metal and its overload causes Wilson disease, a disorder due to mutations in copper transporter ATP7B. To remove excess copper into the bile, ATP7B traffics toward canalicular area of hepatocytes. However, the trafficking mechanisms of ATP7B remain elusive. Here, we...

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Detalles Bibliográficos
Autores principales: Polishchuk, Elena V., Concilli, Mafalda, Iacobacci, Simona, Chesi, Giancarlo, Pastore, Nunzia, Piccolo, Pasquale, Paladino, Simona, Baldantoni, Daniela, van IJzendoorn, Sven C.D., Chan, Jefferson, Chang, Christopher J., Amoresano, Angela, Pane, Francesca, Pucci, Piero, Tarallo, Antonietta, Parenti, Giancarlo, Brunetti-Pierri, Nicola, Settembre, Carmine, Ballabio, Andrea, Polishchuk, Roman S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070386/
https://www.ncbi.nlm.nih.gov/pubmed/24909901
http://dx.doi.org/10.1016/j.devcel.2014.04.033

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