Etanercept-Associated Transient Bone Marrow Aplasia: A Review of the Literature and Pathogenetic Mechanisms

A patient with rheumatoid arthritis presented with increasing fatigue, fever, gingival bleeding, and petechial rash. Her symptoms started 1 week after the first injection of etanercept (Enbrel). Her only other medications (methotrexate and hydroxychloroquine) had been unchanged for years. Tests reve...

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Detalles Bibliográficos
Autores principales: Kozak, Natasha, Friedman, Joshua, Schattner, Ami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070464/
https://www.ncbi.nlm.nih.gov/pubmed/24962606
http://dx.doi.org/10.1007/s40268-014-0050-z
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author Kozak, Natasha
Friedman, Joshua
Schattner, Ami
author_facet Kozak, Natasha
Friedman, Joshua
Schattner, Ami
author_sort Kozak, Natasha
collection PubMed
description A patient with rheumatoid arthritis presented with increasing fatigue, fever, gingival bleeding, and petechial rash. Her symptoms started 1 week after the first injection of etanercept (Enbrel). Her only other medications (methotrexate and hydroxychloroquine) had been unchanged for years. Tests revealed severe pancytopenia and bone marrow aplasia. She recovered with supportive treatment within 12 days. The literature on serious blood dyscrasias associated with anti-tumor necrosis factor-α therapy is reviewed, an intriguing postulated mechanism is discussed, and selective patient monitoring is recommended.
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spelling pubmed-40704642014-07-16 Etanercept-Associated Transient Bone Marrow Aplasia: A Review of the Literature and Pathogenetic Mechanisms Kozak, Natasha Friedman, Joshua Schattner, Ami Drugs R D Short Communication A patient with rheumatoid arthritis presented with increasing fatigue, fever, gingival bleeding, and petechial rash. Her symptoms started 1 week after the first injection of etanercept (Enbrel). Her only other medications (methotrexate and hydroxychloroquine) had been unchanged for years. Tests revealed severe pancytopenia and bone marrow aplasia. She recovered with supportive treatment within 12 days. The literature on serious blood dyscrasias associated with anti-tumor necrosis factor-α therapy is reviewed, an intriguing postulated mechanism is discussed, and selective patient monitoring is recommended. Springer International Publishing 2014-06-11 2014-06 /pmc/articles/PMC4070464/ /pubmed/24962606 http://dx.doi.org/10.1007/s40268-014-0050-z Text en © The Author(s) 2014 https://creativecommons.org/licenses/by-nc/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Short Communication
Kozak, Natasha
Friedman, Joshua
Schattner, Ami
Etanercept-Associated Transient Bone Marrow Aplasia: A Review of the Literature and Pathogenetic Mechanisms
title Etanercept-Associated Transient Bone Marrow Aplasia: A Review of the Literature and Pathogenetic Mechanisms
title_full Etanercept-Associated Transient Bone Marrow Aplasia: A Review of the Literature and Pathogenetic Mechanisms
title_fullStr Etanercept-Associated Transient Bone Marrow Aplasia: A Review of the Literature and Pathogenetic Mechanisms
title_full_unstemmed Etanercept-Associated Transient Bone Marrow Aplasia: A Review of the Literature and Pathogenetic Mechanisms
title_short Etanercept-Associated Transient Bone Marrow Aplasia: A Review of the Literature and Pathogenetic Mechanisms
title_sort etanercept-associated transient bone marrow aplasia: a review of the literature and pathogenetic mechanisms
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070464/
https://www.ncbi.nlm.nih.gov/pubmed/24962606
http://dx.doi.org/10.1007/s40268-014-0050-z
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AT schattnerami etanerceptassociatedtransientbonemarrowaplasiaareviewoftheliteratureandpathogeneticmechanisms

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