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The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study

Purpose. The aim was to compare the effects of antiglaucoma eye drops on the tear functions and ocular surface. Method. Eighty-five eyes of 43 patients with glaucoma were included into this randomized prospective study. Timolol without preservative (1), timolol with benzododecinium bromide (2), lata...

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Autores principales: Aydin Kurna, Sevda, Acikgoz, Semih, Altun, Ahmet, Ozbay, Nurver, Sengor, Tomris, Olcaysu, Osman Okan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070470/
https://www.ncbi.nlm.nih.gov/pubmed/25009742
http://dx.doi.org/10.1155/2014/460483
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author Aydin Kurna, Sevda
Acikgoz, Semih
Altun, Ahmet
Ozbay, Nurver
Sengor, Tomris
Olcaysu, Osman Okan
author_facet Aydin Kurna, Sevda
Acikgoz, Semih
Altun, Ahmet
Ozbay, Nurver
Sengor, Tomris
Olcaysu, Osman Okan
author_sort Aydin Kurna, Sevda
collection PubMed
description Purpose. The aim was to compare the effects of antiglaucoma eye drops on the tear functions and ocular surface. Method. Eighty-five eyes of 43 patients with glaucoma were included into this randomized prospective study. Timolol without preservative (1), timolol with benzododecinium bromide (2), latanoprost (3), bimatoprost (4), travoprost with benzalkonium chloride (5), and brimonidine with purite (6) were given to 6 groups. Schirmer I, tear film breakup time (TBUT), staining scores, and impression cytology samples were evaluated before and during 12-month-follow-up period. Results. At the end of 12 months, there was no detected change in Schirmer I and TBUT tests indicating dry eye. Corneal staining scores were higher in groups 1 and 2, while conjunctival staining scores were higher in group 6. Goblet cell count decreased in groups 1 and 5 in superior and inferior, group 2 in superior, and groups 3 and 6 in inferior conjunctiva. Squamous metaplasia grades showed a significant increase in groups 1 and 2 at 3rd, 6th, and 12th month controls (P < 0.05). Conclusion. We observed nonserious impact on tear functions and ocular surface with antiglaucoma monotherapy. Beta blockers induced more damage on the ocular surface suggesting the role of the dosing and active substances beside preservatives.
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spelling pubmed-40704702014-07-09 The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study Aydin Kurna, Sevda Acikgoz, Semih Altun, Ahmet Ozbay, Nurver Sengor, Tomris Olcaysu, Osman Okan J Ophthalmol Clinical Study Purpose. The aim was to compare the effects of antiglaucoma eye drops on the tear functions and ocular surface. Method. Eighty-five eyes of 43 patients with glaucoma were included into this randomized prospective study. Timolol without preservative (1), timolol with benzododecinium bromide (2), latanoprost (3), bimatoprost (4), travoprost with benzalkonium chloride (5), and brimonidine with purite (6) were given to 6 groups. Schirmer I, tear film breakup time (TBUT), staining scores, and impression cytology samples were evaluated before and during 12-month-follow-up period. Results. At the end of 12 months, there was no detected change in Schirmer I and TBUT tests indicating dry eye. Corneal staining scores were higher in groups 1 and 2, while conjunctival staining scores were higher in group 6. Goblet cell count decreased in groups 1 and 5 in superior and inferior, group 2 in superior, and groups 3 and 6 in inferior conjunctiva. Squamous metaplasia grades showed a significant increase in groups 1 and 2 at 3rd, 6th, and 12th month controls (P < 0.05). Conclusion. We observed nonserious impact on tear functions and ocular surface with antiglaucoma monotherapy. Beta blockers induced more damage on the ocular surface suggesting the role of the dosing and active substances beside preservatives. Hindawi Publishing Corporation 2014 2014-06-09 /pmc/articles/PMC4070470/ /pubmed/25009742 http://dx.doi.org/10.1155/2014/460483 Text en Copyright © 2014 Sevda Aydin Kurna et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Aydin Kurna, Sevda
Acikgoz, Semih
Altun, Ahmet
Ozbay, Nurver
Sengor, Tomris
Olcaysu, Osman Okan
The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study
title The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study
title_full The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study
title_fullStr The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study
title_full_unstemmed The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study
title_short The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study
title_sort effects of topical antiglaucoma drugs as monotherapy on the ocular surface: a prospective study
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070470/
https://www.ncbi.nlm.nih.gov/pubmed/25009742
http://dx.doi.org/10.1155/2014/460483
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