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The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study
Purpose. The aim was to compare the effects of antiglaucoma eye drops on the tear functions and ocular surface. Method. Eighty-five eyes of 43 patients with glaucoma were included into this randomized prospective study. Timolol without preservative (1), timolol with benzododecinium bromide (2), lata...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070470/ https://www.ncbi.nlm.nih.gov/pubmed/25009742 http://dx.doi.org/10.1155/2014/460483 |
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author | Aydin Kurna, Sevda Acikgoz, Semih Altun, Ahmet Ozbay, Nurver Sengor, Tomris Olcaysu, Osman Okan |
author_facet | Aydin Kurna, Sevda Acikgoz, Semih Altun, Ahmet Ozbay, Nurver Sengor, Tomris Olcaysu, Osman Okan |
author_sort | Aydin Kurna, Sevda |
collection | PubMed |
description | Purpose. The aim was to compare the effects of antiglaucoma eye drops on the tear functions and ocular surface. Method. Eighty-five eyes of 43 patients with glaucoma were included into this randomized prospective study. Timolol without preservative (1), timolol with benzododecinium bromide (2), latanoprost (3), bimatoprost (4), travoprost with benzalkonium chloride (5), and brimonidine with purite (6) were given to 6 groups. Schirmer I, tear film breakup time (TBUT), staining scores, and impression cytology samples were evaluated before and during 12-month-follow-up period. Results. At the end of 12 months, there was no detected change in Schirmer I and TBUT tests indicating dry eye. Corneal staining scores were higher in groups 1 and 2, while conjunctival staining scores were higher in group 6. Goblet cell count decreased in groups 1 and 5 in superior and inferior, group 2 in superior, and groups 3 and 6 in inferior conjunctiva. Squamous metaplasia grades showed a significant increase in groups 1 and 2 at 3rd, 6th, and 12th month controls (P < 0.05). Conclusion. We observed nonserious impact on tear functions and ocular surface with antiglaucoma monotherapy. Beta blockers induced more damage on the ocular surface suggesting the role of the dosing and active substances beside preservatives. |
format | Online Article Text |
id | pubmed-4070470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40704702014-07-09 The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study Aydin Kurna, Sevda Acikgoz, Semih Altun, Ahmet Ozbay, Nurver Sengor, Tomris Olcaysu, Osman Okan J Ophthalmol Clinical Study Purpose. The aim was to compare the effects of antiglaucoma eye drops on the tear functions and ocular surface. Method. Eighty-five eyes of 43 patients with glaucoma were included into this randomized prospective study. Timolol without preservative (1), timolol with benzododecinium bromide (2), latanoprost (3), bimatoprost (4), travoprost with benzalkonium chloride (5), and brimonidine with purite (6) were given to 6 groups. Schirmer I, tear film breakup time (TBUT), staining scores, and impression cytology samples were evaluated before and during 12-month-follow-up period. Results. At the end of 12 months, there was no detected change in Schirmer I and TBUT tests indicating dry eye. Corneal staining scores were higher in groups 1 and 2, while conjunctival staining scores were higher in group 6. Goblet cell count decreased in groups 1 and 5 in superior and inferior, group 2 in superior, and groups 3 and 6 in inferior conjunctiva. Squamous metaplasia grades showed a significant increase in groups 1 and 2 at 3rd, 6th, and 12th month controls (P < 0.05). Conclusion. We observed nonserious impact on tear functions and ocular surface with antiglaucoma monotherapy. Beta blockers induced more damage on the ocular surface suggesting the role of the dosing and active substances beside preservatives. Hindawi Publishing Corporation 2014 2014-06-09 /pmc/articles/PMC4070470/ /pubmed/25009742 http://dx.doi.org/10.1155/2014/460483 Text en Copyright © 2014 Sevda Aydin Kurna et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Aydin Kurna, Sevda Acikgoz, Semih Altun, Ahmet Ozbay, Nurver Sengor, Tomris Olcaysu, Osman Okan The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study |
title | The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study |
title_full | The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study |
title_fullStr | The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study |
title_full_unstemmed | The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study |
title_short | The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study |
title_sort | effects of topical antiglaucoma drugs as monotherapy on the ocular surface: a prospective study |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070470/ https://www.ncbi.nlm.nih.gov/pubmed/25009742 http://dx.doi.org/10.1155/2014/460483 |
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