Highly stereoselective biosynthesis of (R)-α-hydroxy carboxylic acids through rationally re-designed mutation of d-lactate dehydrogenase

An NAD-dependent d-lactate dehydrogenase (d-nLDH) of Lactobacillus bulgaricus ATCC 11842 was rationally re-designed for asymmetric reduction of a homologous series of α-keto carboxylic acids such as phenylpyruvic acid (PPA), α-ketobutyric acid, α-ketovaleric acid, β-hydroxypyruvate. Compared with wi...

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Detalles Bibliográficos
Autores principales: Zheng, Zhaojuan, Sheng, Binbin, Gao, Chao, Zhang, Haiwei, Qin, Tong, Ma, Cuiqing, Xu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070498/
https://www.ncbi.nlm.nih.gov/pubmed/24292439
http://dx.doi.org/10.1038/srep03401

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