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Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism
Background. N-Glycolylneuraminic acid (Neu5Gc) is a sialic acid synthesized by animals, but not by humans or birds. However, it can be incorporated in human cells and can trigger immune response. In the present study, we detected anti-Neu5Gc antibodies in samples of the general population and of pat...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070528/ https://www.ncbi.nlm.nih.gov/pubmed/25003133 http://dx.doi.org/10.1155/2014/963230 |
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author | Eleftheriou, Phaedra Kynigopoulos, Stavros Giovou, Alexandra Mazmanidi, Alexandra Yovos, John Skepastianos, Petros Vagdatli, Eleni Petrou, Christos Papara, Dafni Efterpiou, Maria |
author_facet | Eleftheriou, Phaedra Kynigopoulos, Stavros Giovou, Alexandra Mazmanidi, Alexandra Yovos, John Skepastianos, Petros Vagdatli, Eleni Petrou, Christos Papara, Dafni Efterpiou, Maria |
author_sort | Eleftheriou, Phaedra |
collection | PubMed |
description | Background. N-Glycolylneuraminic acid (Neu5Gc) is a sialic acid synthesized by animals, but not by humans or birds. However, it can be incorporated in human cells and can trigger immune response. In the present study, we detected anti-Neu5Gc antibodies in samples of the general population and of patients suffering from hypothyroidism/Hashimoto's disease, which is known to have autoimmune origin. Methods. Antibodies were measured using enzyme-immunosorbent techniques. Results. Serum anti-Neu5Gc IgG antibodies were higher in patients with hypothyroidism (mean: 14.8 ± 15.9 μg/mL, median: 10.0 μg/mL, P = 0.0003, Mann-Whitney) and even higher in the group with Hashimoto's thyroiditis (mean: 31.1 ± 16.3 μg/mL, median: 27.2 μg/mL, P = 0.0000, Mann-Whitney) compared to the general population (mean: 5.3 ± 4.7 μg/mL, median : 4 μg/mL). All anti-TPO positive samples had anti-Neu5Gc antibody concentration higher than the mean value of the general population while anti-TPO concentration was increased as anti-Neu5Gc concentration increased. Low concentrations of IgA and IgM antibodies were measured in both general population and patient groups. Conclusion. The increased values of anti-Neu5Gc antibodies in patients with hypothyroidism/Hashimoto's disease and the correlation of anti-TPO incidence with increased anti-Neu5Gc concentration raise the possibility of an association between anti-Neu5Gc antibody development and autoimmune hypothyroidism. |
format | Online Article Text |
id | pubmed-4070528 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40705282014-07-07 Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism Eleftheriou, Phaedra Kynigopoulos, Stavros Giovou, Alexandra Mazmanidi, Alexandra Yovos, John Skepastianos, Petros Vagdatli, Eleni Petrou, Christos Papara, Dafni Efterpiou, Maria Biomed Res Int Research Article Background. N-Glycolylneuraminic acid (Neu5Gc) is a sialic acid synthesized by animals, but not by humans or birds. However, it can be incorporated in human cells and can trigger immune response. In the present study, we detected anti-Neu5Gc antibodies in samples of the general population and of patients suffering from hypothyroidism/Hashimoto's disease, which is known to have autoimmune origin. Methods. Antibodies were measured using enzyme-immunosorbent techniques. Results. Serum anti-Neu5Gc IgG antibodies were higher in patients with hypothyroidism (mean: 14.8 ± 15.9 μg/mL, median: 10.0 μg/mL, P = 0.0003, Mann-Whitney) and even higher in the group with Hashimoto's thyroiditis (mean: 31.1 ± 16.3 μg/mL, median: 27.2 μg/mL, P = 0.0000, Mann-Whitney) compared to the general population (mean: 5.3 ± 4.7 μg/mL, median : 4 μg/mL). All anti-TPO positive samples had anti-Neu5Gc antibody concentration higher than the mean value of the general population while anti-TPO concentration was increased as anti-Neu5Gc concentration increased. Low concentrations of IgA and IgM antibodies were measured in both general population and patient groups. Conclusion. The increased values of anti-Neu5Gc antibodies in patients with hypothyroidism/Hashimoto's disease and the correlation of anti-TPO incidence with increased anti-Neu5Gc concentration raise the possibility of an association between anti-Neu5Gc antibody development and autoimmune hypothyroidism. Hindawi Publishing Corporation 2014 2014-06-09 /pmc/articles/PMC4070528/ /pubmed/25003133 http://dx.doi.org/10.1155/2014/963230 Text en Copyright © 2014 Phaedra Eleftheriou et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Eleftheriou, Phaedra Kynigopoulos, Stavros Giovou, Alexandra Mazmanidi, Alexandra Yovos, John Skepastianos, Petros Vagdatli, Eleni Petrou, Christos Papara, Dafni Efterpiou, Maria Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism |
title | Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism |
title_full | Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism |
title_fullStr | Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism |
title_full_unstemmed | Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism |
title_short | Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism |
title_sort | prevalence of anti-neu5gc antibodies in patients with hypothyroidism |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070528/ https://www.ncbi.nlm.nih.gov/pubmed/25003133 http://dx.doi.org/10.1155/2014/963230 |
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