Amyloid Beta-Mediated Epigenetic Alteration of Insulin-Like Growth Factor Binding Protein 3 Controls Cell Survival in Alzheimer's Disease

Swedish double mutation (KM670/671NL) of amyloid precursor protein (APP) is reported to increase toxic amyloid β (Aβ) production via aberrant cleavage at the β-secretase site and thereby cause early-onset Alzheimer's disease (AD). However, the underlying molecular mechanisms leading to AD patho...

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Detalles Bibliográficos
Autores principales: Sung, Hye Youn, Choi, Eun Nam, Lyu, Dahyun, Mook-Jung, Inhee, Ahn, Jung-Hyuck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070895/
https://www.ncbi.nlm.nih.gov/pubmed/24964199
http://dx.doi.org/10.1371/journal.pone.0099047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070895/
https://www.ncbi.nlm.nih.gov/pubmed/24964199
http://dx.doi.org/10.1371/journal.pone.0099047

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