Skin Fibroblasts from Patients with Type 1 Diabetes (T1D) Can Be Chemically Transdifferentiated into Insulin-Expressing Clusters: A Transgene-Free Approach

The conversion of differentiated cells into insulin-producing cells is a promising approach for the autologous replacement of pancreatic cells in patients with type 1 diabetes (T1D). At present, cellular reprogramming strategies encompass ethical problems, epigenetic failure or teratoma formation, w...

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Detalles Bibliográficos
Autores principales: Pereyra-Bonnet, Federico, Gimeno, María L., Argumedo, Nelson R., Ielpi, Marcelo, Cardozo, Johana A., Giménez, Carla A., Hyon, Sung-Ho, Balzaretti, Marta, Loresi, Mónica, Fainstein-Day, Patricia, Litwak, León E., Argibay, Pablo F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070975/
https://www.ncbi.nlm.nih.gov/pubmed/24963634
http://dx.doi.org/10.1371/journal.pone.0100369

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