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Dose Responsive Effects of Subcutaneous Pentosan Polysulfate Injection in Mucopolysaccharidosis Type VI Rats and Comparison to Oral Treatment

BACKGROUND: We previously demonstrated the benefits of daily, oral pentosan polysulfate (PPS) treatment in a rat model of mucopolysaccharidosis (MPS) type VI. Herein we compare these effects to once weekly, subcutaneous (sc) injection. The bioavailability of injected PPS is greater than oral, sugges...

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Detalles Bibliográficos
Autores principales:	Frohbergh, Michael, Ge, Yi, Meng, Fanli, Karabul, Nesrin, Solyom, Alexander, Lai, Alon, Iatridis, James, Schuchman, Edward H., Simonaro, Calogera M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071040/ https://www.ncbi.nlm.nih.gov/pubmed/24964042 http://dx.doi.org/10.1371/journal.pone.0100882

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