Fatty Acid Synthase Inhibitors Induce Apoptosis in Non-Tumorigenic Melan-A Cells Associated with Inhibition of Mitochondrial Respiration

The metabolic enzyme fatty acid synthase (FASN) is responsible for the endogenous synthesis of palmitate, a saturated long-chain fatty acid. In contrast to most normal tissues, a variety of human cancers overexpress FASN. One such cancer is cutaneous melanoma, in which the level of FASN expression i...

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Detalles Bibliográficos
Autores principales: Rossato, Franco A., Zecchin, Karina G., La Guardia, Paolo G., Ortega, Rose M., Alberici, Luciane C., Costa, Rute A. P., Catharino, Rodrigo R., Graner, Edgard, Castilho, Roger F., Vercesi, Aníbal E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071076/
https://www.ncbi.nlm.nih.gov/pubmed/24964211
http://dx.doi.org/10.1371/journal.pone.0101060

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